| Pos | Pos+ | Artist and Title | Days | Peak | Pts | Released |
| 1 | +1 | Bruno Mars - Grenade | 78 | 1(3) | 1.063 | 10/5/10 |
| 2 | -1 | Lil Wayne - 6 Foot 7 Foot (feat. Cory Gunz) | 6 | 1(5) | 0.208 | 12/16/10 |
| 3 | = | Katy Perry - Firework | 68 | 1(22) | 1.558 | 8/24/10 |
| 4 | = | The Black Eyed Peas - The Time (Dirty Bit) | 22 | 3 | 0.467 | 11/30/10 |
| 5 | = | Ke$ha - We R Who We R | 58 | 1(15) | 1.495 | 10/22/10 |
| 6 | = | Rihanna & Drake - What's My Name? | 36 | 3 | 0.691 | 11/16/10 |
| 7 | +4 | The Lonely Island - I Just Had Sex (feat. Akon) | 3 | 7 | 0.039 | 12/19/10 |
| 8 | +1 | Diddy - Dirty Money & Skylar Grey - Coming Home | 8 | 8 | 0.082 | 12/14/10 |
| 9 | -1 | P!nk - Raise Your Glass | 76 | 3 | 1.349 | 10/6/10 |
| 10 | +2 | Enrique Iglesias - Tonight (I'm Lovin' You) [feat. Luda... | 30 | 10 | 0.179 | 1/11/11 |
| 11 | -1 | Trey Songz - Bottoms Up (feat. Nicki Minaj) | 99 | 5 | 1.307 | 9/14/10 |
| 12 | +1 | Bruno Mars - Just the Way You Are | 155 | 1(12) | 2.856 | 7/20/10 |
| 13 | +1 | Nelly - Just a Dream | 128 | 2 | 2.291 | 8/17/10 |
| 14 | +2 | Edward Maya & Vika Jigulina - Stereo Love | 73 | 12 | 0.491 | 2/2/10 |
| 15 | = | Rihanna - Only Girl (In the World) | 14 | 12 | 0.136 | 11/16/10 |
| 16 | +1 | Waka Flocka Flame - No Hands (feat. Roscoe Dash & Wale) | 106 | 14 | 0.744 | 9/6/10 |
| 17 | +2 | Taio Cruz - Dynamite | 202 | 1(6) | 3.406 | 6/1/10 |
| 18 | = | Far East Movement, The Cataracs & Dev - Like a G6 | 141 | 1(16) | 2.477 | 10/9/10 |
| 19 | +1 | Chris Brown - Yeah 3X | 58 | 12 | 0.334 | 10/25/10 |
| 20 | +3 | Usher - DJ Got Us Fallin' In Love (feat. Pitbull) | 162 | 2 | 2.292 | 6/25/10 |
| 21 | +1 | Mike Posner - Please Don't Go | 82 | 12 | 0.658 | 8/10/10 |
| 22 | +4 | Pitbull - Hey Baby (Drop It to the Floor) [feat. T-Pain... | 85 | 16 | 0.525 | 9/17/10 |
| 23 | +1 | OneRepublic - Secrets | 181 | 16 | 1.166 | 11/17/09 |
| 24 | +4 | Cee Lo Green - F**k You | 96 | 6 | 0.830 | 9/14/10 |
| 25 | +2 | The Band Perry - If I Die Young | 70 | 14 | 0.491 | 10/12/10 |
| 26 | -1 | Willow - Whip My Hair | 58 | 2 | 0.643 | 10/26/10 |
| 27 | +133 | Taio Cruz & Travie McCoy - Higher (feat. Travie McCoy) | 1 | 27 | 0.008 | 12/20/10 |
| 28 | +1 | Christina Perri - Jar of Hearts | 68 | 27 | 0.407 | 7/27/10 |
| 29 | +1 | Taylor Swift - Back to December | 55 | 29 | 0.259 | 10/25/10 |
| 30 | -9 | Michael Jackson - Hold My Hand (Duet with Akon) | 8 | 21 | 0.055 | 12/14/10 |
| 31 | +219 | 3OH!3 - Hit It Again | 1 | 31 | 0.007 | 12/21/10 |
| 32 | = | Neon Trees - Animal | 202 | 12 | 1.230 | 3/16/10 |
| 33 | -2 | Eminem - No Love (feat. Lil Wayne) | 127 | 8 | 0.702 | 6/21/10 |
| 34 | -1 | Far East Movement & Ryan Tedder - Rocketeer | 12 | 33 | 0.095 | 10/9/10 |
| 35 | -1 | Mariah Carey - All I Want for Christmas Is You (Origina... | 32 | 18 | 0.209 | 12/31/93 |
| 36 | +1 | Flo Rida - Club Can't Handle Me (feat. David Guetta) [F... | 172 | 5 | 1.805 | 6/28/10 |
| 37 | +1 | Kenny Chesney - Somewhere With You | 50 | 31 | 0.247 | 9/28/10 |
| 38 | -3 | Sugarland - Stuck Like Glue | 55 | 9 | 0.372 | 10/19/10 |
| 39 | = | Florence + The Machine - Dog Days Are Over | 120 | 3 | 0.712 | 7/5/09 |
| 40 | -4 | The Ready Set - Love Like Woe | 149 | 14 | 0.853 | 6/14/10 |
| 41 | = | Katy Perry - Teenage Dream | 152 | 1(16) | 2.437 | 7/23/10 |
| 42 | = | Jason Aldean - Don't You Wanna Stay (with Kelly Clarkso... | 49 | 18 | 0.209 | 11/2/10 |
| 43 | = | Lil Wayne & Drake - Right Above It | 34 | 39 | 0.153 | 11/16/10 |
| 44 | +2 | Dr. Dre - Kush (feat. Snoop Dogg & Akon) | 34 | 12 | 0.214 | 11/18/10 |
| 45 | -5 | T.I. - That's All She Wrote (feat. Eminem) | 16 | 4 | 0.222 | 12/7/10 |
| 46 | +317 | B.o.B - I Am the Champion | 1 | 46 | 0.005 | 12/21/10 |
| 47 | +2 | Jeremih & 50 Cent - Down On Me (feat. 50 Cent) | 43 | 33 | 0.211 | 9/28/10 |
| 48 | -3 | Enrique Iglesias - Tonight (I'm F**kin' You) [feat. Lud... | 30 | 13 | 0.232 | 1/11/11 |
| 49 | -5 | Keri Hilson - Pretty Girl Rock | 36 | 34 | 0.168 | 10/12/10 |
| 50 | +231 | Hollywood Undead - Hear Me Now | 1 | 50 | 0.005 | 12/21/10 |
| 51 | -3 | Tim McGraw - Felt Good On My Lips | 21 | 48 | 0.083 | 11/30/10 |
| 52 | -5 | Eminem - Love the Way You Lie (feat. Rihanna) | 185 | 1(33) | 3.080 | 6/21/10 |
| 53 | +225 | Sean Kingston - Party All Night (Sleep All Day) | 1 | 53 | 0.005 | 12/21/10 |
| 54 | -1 | Sara Bareilles - King of Anything | 106 | 16 | 0.450 | 9/7/10 |
| 55 | -3 | Eminem - Not Afraid | 190 | 5 | 1.684 | 6/21/10 |
| 56 | +114 | Kanye West, Prynce Cy Hi & Teyana Taylor - Christmas In... | 1 | 56 | 0.007 | 12/17/10 |
| 57 | +632 | Brad Paisley - This Is Country Music | 1 | 57 | 0.004 | 12/21/10 |
| 58 | -7 | Yolanda Be Cool & Dcup - We No Speak Americano | 104 | 16 | 0.646 | 7/20/10 |
| 59 | -5 | Taylor Swift - Mine | 58 | 16 | 0.281 | 10/25/10 |
| 60 | -5 | Nicki Minaj - Right Thru Me | 27 | 34 | 0.114 | 11/22/10 |
| 61 | -4 | Jason Aldean - My Kinda Party | 49 | 33 | 0.191 | 11/2/10 |
| 62 | -4 | Blake Shelton - Who Are You When I'm Not Looking | 46 | 58 | 0.202 | 8/6/10 |
| 63 | -7 | P!nk - Raise Your Glass | 58 | 39 | 0.226 | 10/6/10 |
| 64 | -14 | Victorious Cast - Freak the Freak Out (feat. Victoria J... | 24 | 13 | 0.122 | 11/22/10 |
| 65 | -5 | Train - Hey, Soul Sister | 190 | 14 | 1.042 | 8/7/09 |
| 66 | -7 | Flo Rida - Who Dat Girl (feat. Akon) | 22 | 22 | 0.100 | 11/24/10 |
| 67 | +753 | Wiz Khalifa - Black and Yellow | 1 | 67 | 0.004 | 12/21/10 |
| 68 | -6 | Mumford & Sons - Little Lion Man | 137 | 38 | 0.600 | 2/16/10 |
| 69 | -6 | Plain White T's - Rhythm of Love | 13 | 54 | 0.050 | 12/7/10 |
| 70 | -5 | Enrique Iglesias - I Like It (feat. Pitbull) | 202 | 3 | 2.357 | 5/3/10 |
| 71 | -4 | B.o.B - Magic (feat. Rivers Cuomo) | 172 | 6 | 1.431 | 4/27/10 |
| 72 | +6 | Birdman & Lil Wayne - Fire Flame (feat. Lil Wayne) | 21 | 54 | 0.083 | 11/22/10 |
| 73 | -1 | Billy Currington - Let Me Down Easy | 12 | 72 | 0.122 | 9/21/10 |
| 74 | -3 | Bruno Mars - Marry You | 32 | 37 | 0.135 | 10/5/10 |
| 75 | +8 | Usher - More | 4 | 75 | 0.027 | 3/30/10 |
| 76 | -1 | Glee Cast - Last Christmas (Glee Cast Version) | 15 | 16 | 0.102 | 11/16/10 |
| 77 | +2 | Rick Ross - Aston Martin Music (feat. Drake & Chrisette... | 69 | 32 | 0.288 | 7/20/10 |
| 78 | -17 | Dev & The Cataracs - Bass Down Low (feat. The Cataracs) | 15 | 41 | 0.055 | 12/7/10 |
| 79 | -6 | The Black Eyed Peas - I Gotta Feeling | 199 | 31 | 0.727 | 6/9/09 |
| 80 | -6 | Train - Marry Me | 27 | 58 | 0.157 | 10/26/09 |
| 81 | -13 | Ke$ha - Take It Off | 147 | 6 | 1.326 | 1/4/09 |
| 82 | -13 | Akon - Angel | 57 | 20 | 0.290 | 9/17/10 |
| 83 | -17 | Daft Punk - Derezzed | 5 | 66 | 0.033 | 12/7/10 |
| 84 | +668 | Jamie Foxx - Fall for Your Type (feat. Drake) | 1 | 84 | 0.003 | 12/17/10 |
| 85 | -5 | Thompson Square - Are You Gonna Kiss Me or Not | 9 | 80 | 0.132 | 8/3/10 |
| 86 | -9 | David Guetta - Memories | 41 | 72 | 0.227 | 3/26/10 |
| 87 | +168 | Katy Perry - California Gurls (feat. Snoop Dogg) | 10 | 52 | 0.098 | 8/24/10 |
| 88 | +20 | Lil Wayne & Cory Gunz - 6 Foot 7 Foot (feat. Cory Gunz) | 1 | 88 | 0.013 | 12/16/10 |
| 89 | -4 | Trans-Siberian Orchestra - Christmas / Sarajevo 12/24 (... | 25 | 63 | 0.095 | 10/14/96 |
| 90 | +1 | Coldplay - Christmas Lights | 21 | 3 | 0.197 | 12/1/10 |
| 91 | +1 | Glee Cast - Baby, It's Cold Outside (Glee Cast Version) | 18 | 14 | 0.123 | 11/16/10 |
| 92 | -28 | P!nk - F**kin' Perfect | 8 | 44 | 0.033 | 12/14/10 |
| 93 | -7 | Mike Posner - Cooler Than Me (Single Mix) | 178 | 4 | 2.088 | 4/19/10 |
| 94 | -5 | Kanye West & Pusha T - Runaway | 29 | 52 | 0.097 | 11/22/10 |
| 95 | -5 | Zac Brown Band - As She's Walking Away (feat. Alan Jack... | 90 | 29 | 0.350 | 9/20/10 |
| 96 | -14 | Coldplay - Fix You | 2 | 82 | 0.021 | 6/7/05 |
| 97 | +9 | Train - Shake Up Christmas (Coke Xmas Anthem) | 1 | 97 | 0.022 | 11/1/10 |
| 98 | -11 | Cali Swag District - Teach Me How to Dougie | 7 | 84 | 0.041 | 4/6/10 |
| 99 | -2 | Cee Lo Green - Forget You | 54 | 17 | 0.280 | 9/14/10 |
| 100 | -5 | Troop 41 - Do The John Wall | 2 | 95 | 0.007 | 11/19/10 |
| 101 | -8 | Sean Kingston - Letting Go (Dutty Love) [feat. Nicki Mi... | 139 | 14 | 0.778 | 8/3/10 |
| 104 | -5 | Sara Evans - A Little Bit Stronger | 21 | 48 | 0.221 | 9/14/10 |
| 108 | -38 | Thurl Ravenscroft - You're a Mean One Mr. Grinch | 14 | 26 | 0.082 | 6/30/95 |
| 110 | +4 | Jerrod Niemann - What Do You Want | -- | 110 | 0.124 | 7/13/10 |
| 111 | +39 | Street Corner Symphony - Down On the Corner | -- | 111 | 0.011 | 12/15/10 |
| 112 | -28 | Coldplay - Viva la Vida | 19 | 71 | 0.167 | 6/11/08 |
| 117 | +263 | Avenged Sevenfold - Welcome to the Family | -- | 117 | 0.003 | 12/17/10 |
| 119 | -21 | Usher - OMG (feat. will.i.am) | 157 | 2 | 1.678 | 3/30/10 |
| 121 | NEW | Jimmy Fallon - Drunk On Christmas (feat. John Rich) [Li... | -- | 121 | 0.002 | 12/21/10 |
| 122 | -46 | John Lennon, The Harlem Community Choir, Yoko Ono & The... | 14 | 25 | 0.068 | 10/1/10 |
| 129 | -33 | Taio Cruz - Higher | 3 | 87 | 0.030 | 6/1/10 |
| 134 | -53 | Dean Martin - Baby, It's Cold Outside | 14 | 32 | 0.063 | 11/15/59 |
| 150 | +369 | Avenged Sevenfold - 4:00 Am | -- | 150 | 0.002 | 12/17/10 |
| 151 | NEW | Keri Hilson - Pretty Girl Rock | -- | 151 | 0.002 | 12/21/10 |
| 153 | -65 | The Chipmunks - The Chipmunk Song (Christmas Don't Be L... | 14 | 31 | 0.071 | 12/31/61 |
| 155 | NEW | Keri Hilson & Rick Ross - The Way You Love Me | -- | 155 | 0.002 | 12/21/10 |
| 173 | NEW | Meredith Brooks - Bitch | -- | 173 | 0.002 | 4/24/97 |
| 178 | +808 | Jamie Foxx - Best Night of My Life (feat. Wiz Khalifa) | -- | 178 | 0.002 | 12/17/10 |
| 180 | NEW | Jamie Foxx - Yep Dat's Me (feat. Ludacris & Soulja Boy) | -- | 180 | 0.001 | 12/17/10 |
| 185 | NEW | Wild Cherry - Play That Funky Music | -- | 185 | 0.004 | 12/31/75 |
| 189 | +708 | MC Hammer - U Can't Touch This | -- | 110 | 0.052 | 9/9/96 |
| 195 | +735 | The Verve Pipe - The Freshmen | -- | 195 | 0.001 | 3/25/96 |
| 202 | +688 | Poison - Every Rose Has Its Thorn | -- | 159 | 0.044 | 4/4/06 |
| 203 | NEW | Vampire Weekend - I'm Going Down (iTunes Session) | -- | 203 | 0.001 | 12/21/10 |
| 205 | +648 | Fugees - Killing Me Softly With His Song | -- | 205 | 0.006 | 4/1/03 |
| 206 | NEW | Flyleaf - How He Loves (Live) | -- | 206 | 0.001 | 12/21/10 |
| 210 | NEW | Rob Base & DJ EZ Rock - It Takes Two | -- | 210 | 0.001 | 10/27/09 |
| 211 | NEW | Dexy's Midnight Runners & Kevin Rowland - Come On Eilee... | -- | 211 | 0.001 | 4/3/07 |
| 212 | +388 | The Verve - Bitter Sweet Symphony | 9 | 69 | 0.110 | 9/29/97 |
| 216 | NEW | Keyshia Cole & Nicki Minaj - I Ain't Thru | -- | 216 | 0.001 | 12/21/10 |
| 219 | +140 | Grace Potter & The Nocturnals - Paris (Ooh La La) | -- | 127 | 0.031 | 6/8/10 |
| 223 | +158 | Street Corner Symphony - Creep (Studio Version) | -- | 223 | 0.002 | 12/20/10 |
| 235 | NEW | Crazy Town - Butterfly | -- | 235 | 0.001 | 10/25/99 |
| 237 | +748 | The Steve Miller Band - The Joker | -- | 190 | 0.032 | 12/31/77 |
| 241 | +738 | Saving Abel - Addicted | -- | 241 | 0.022 | 3/11/08 |
| 244 | +147 | Committed - Apologize (Studio Version) | -- | 244 | 0.002 | 12/20/10 |
| 252 | NEW | Matchbox Twenty - 3 AM | -- | 252 | 0.001 | 9/28/07 |
| 253 | +668 | Mariah Carey - Always Be My Baby | -- | 253 | 0.001 | 11/2/98 |
| 259 | +81 | Travis Porter - Make It Rain | -- | 259 | 0.007 | 12/2/10 |
| 260 | NEW | Miranda Cosgrove - Dancing Crazy | -- | 260 | 0.001 | 12/21/10 |
| 271 | NEW | Vertical Horizon - Everything You Want | -- | 271 | 0.001 | 6/15/99 |
| 272 | NEW | Jamie Foxx - Living Better Now (feat. Rick Ross) | -- | 272 | 0.001 | 12/17/10 |
| 275 | NEW | Cody Simpson - All Day | -- | 275 | 0.001 | 12/20/10 |
| 288 | +73 | Eartha Kitt - Santa Baby | -- | 185 | 0.023 | 1/1/06 |
| 296 | +391 | 30 Seconds to Mars - The Kill | -- | 116 | 0.068 | 8/16/05 |
| 297 | NEW | Keri Hilson & Kanye West - Pretty Girl Rock | -- | 297 | 0.001 | 12/21/10 |
| 298 | +587 | Wiz Khalifa - Make It Hot | -- | 298 | 0.002 | 7/28/08 |
| 307 | +142 | Adam Sandler - The Chanukah Song | -- | 109 | 0.033 | 2/12/96 |
| 317 | NEW | C+C Music Factory - Gonna Make You Sweat (Everybody Dan... | -- | 317 | 0.001 | 1/31/96 |
| 319 | +324 | Gorillaz - Feel Good Inc | -- | 166 | 0.078 | 7/27/04 |
| 325 | +426 | The Red Jumpsuit Apparatus - Face Down | -- | 225 | 0.036 | 7/18/06 |
| 326 | NEW | Radiohead - Creep (Explicit Version) | -- | 326 | 0.001 | 4/19/93 |
| 340 | NEW | Jamie Foxx - Winner (feat. Justin Timberlake & T.I.) | -- | 340 | 0.001 | 12/17/10 |
| 352 | NEW | Lonestar - I'm Already There | -- | 352 | 0.001 | 3/27/01 |
| 359 | +128 | Street Corner Symphony - Everybody Wants to Rule the Wo... | -- | 359 | 0.006 | 12/6/10 |
| 370 | NEW | Ricky Martin - Shine | -- | 370 | 0.001 | 12/21/10 |
| 381 | +172 | The Backbeats - Landslide (Studio Version) | -- | 381 | 0.001 | 12/20/10 |
| 389 | NEW | Meat Loaf - I'd Do Anything for Love (But I Won't Do Th... | -- | 389 | 0.001 | 12/31/92 |
| 421 | NEW | Keyshia Cole - Long Way Down | -- | 421 | 0.001 | 12/21/10 |
| 423 | NEW | Keri Hilson & Timbaland - Lie to Me | -- | 423 | 0.001 | 12/21/10 |
| 427 | NEW | Ini Kamoze - Here Comes the Hotstepper (Heartical Mix) | -- | 427 | 0.001 | 3/28/95 |
| 434 | NEW | Sixpence None the Richer - Kiss Me | -- | 434 | 0.001 | 11/21/97 |
| 437 | NEW | Eddie Money - Take Me Home Tonight | -- | 437 | 0.001 | 7/24/01 |
| 442 | NEW | Keri Hilson & Chris Brown - One Night Stand | -- | 442 | 0.001 | 12/21/10 |
| 449 | +494 | Yael Naïm - New Soul | -- | 449 | 0.003 | 10/22/07 |
| 458 | NEW | Marvin Gaye - Sexual Healing | -- | 458 | 0.001 | 11/10/98 |
| 460 | NEW | Smashing Pumpkins - 1979 | -- | 460 | 0.001 | 10/24/95 |
| 474 | NEW | Duran Duran - Rio (US Edit) | -- | 474 | 0.001 | 12/31/97 |
| 475 | NEW | Keri Hilson & J. Cole - Buyou | -- | 475 | 0.001 | 12/21/10 |
| 479 | +465 | The White Stripes - Icky Thump | -- | 479 | 0.012 | 6/6/07 |
| 496 | +372 | Disturbed - Indestructible | -- | 496 | 0.009 | 6/3/08 |
