When you exert all the effort in maintaining the friendship, and the other party doesn't. I have a friend who always wants me to come to where she is, go to where she's near, or meet her where it's convenient for her. She never met me halfway, or exerted the effort to go where I am. I made the decision to stop being friends with her because it's tiring to be friends with someone who doesn't actually care for you in the bigger picture!