The world as we know it will end with a catastrophic meteorite shower. It will wipe the majority of the world's species out. The only species it will not wipe out are small microbes and the tiniest of insects.
Before the event occurs, the world will already be dying due to climate change. After the meteorite shower, it will only further add to the awful conditions, meaning evolution has it happened before will not be able to take place again. Slowly, microbes will no longer be able to live and the insects will slowly become extinct.
Alternate theory: AIs take over the world, all organic living beings will be annihilated, then the robots will build spaceships to leave Earth, after which nothing alive remains on the planet. Eventually the Sun destroys the Earth.