Blurred Lines revived his career and brought him to his highest point in his career, then ruined his career and made it lower than it's ever been all in 1 year.
The same can be said for Fancy.
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You could argue SOS saved Rihanna's career. Music of the Sun bombed after PDR, and nobody was thinking of her. Had it flopped, I doubt the rest of the singles from AGLM would've been able to be hits.
Ciara's Ride. I remember the day the video dropped, how the majority of the audience that gave up on her after LSM was bowing down. And I feel like the song set the down for the second half of her career and started her return as a bit of a staple on urban radio.
Monica's Everything To Me. The way she came back swinging after her 4th album flopped, woo.
Kylie's Confide In Me. For certain countries, it's her only huge song in the 90's, I believe. And her best song obviously