The 33-year-old's scripted comedy, which is about her childhood before she became a household name, began filming on Monday in Jamaica, Queens.
Ariana Neal, who plays the rapper as a child, was spotted filming the pilot episode of 'Nicki' while cleaning graffiti off the wall in the New York City neighborhood.
The 10-year-old actress wore a bright pink jacket with animal print patterned lining, which she paired with grey jeans, black boots and a white hair tie.
Nicki revealed last fall that model Selita Ebanks will play her mother, Wesley Jonathan as her dad, McCarrie McCausland as her brother, and Whoopi Goldberg as their neighbor, Miss Martha.
The sitcom, written by Kate Angelo and directed by Tim Story, does not have a set premiere date yet.