There are so many and they're so different. That's what I like about the US. LA, NYC, DC, Las Vegas, Orlando, New Orleans, San Francisco, Seattle, Miami, etc...
depends what you're the most interested in. art, history, cuisine, nature, beaches, night life, attractions??
new york, miami, chicago
new orleans and philadelphia are great too
West Philadelphia boy here!!
Philadelphia is a great city with a lot of history and culture and excellent food too such as The Cheesesteak, The Soft Pretzel, Italian Ice and cream cheese all originated from Philly!
We also have the largest Italian and Spanish community in the country only behind NYC
Will Smith and Patti Labelle both grew up down the block from where I grew up at!
Manhattan. Ridden with entitled homeless people, the 1%, ironic ANTi hipsters, and you can smell the halal carts a mile into the sky, but it's the best place in the worldUS.