No. We Found Love is the biggest female-led hit of the past decade, according to Billboard's All Time Hot 100, followed by Rolling in the Deep, Call Me Maybe, TiK ToK, and No One. Poker Face didn't make the list. A SMASH is more than digital singles sold.
And if you're referring to the 2000-2009 decade as opposed to the past ten years, TiK ToK and No One are.
