Yes of course! I used to always smoke an indica to relax, which just made me lethargic, albeit euphoric, so I recently switched to sativa and my life has changed for the better ever since. Sativa really helps with depression and anxiety, even after the high has worn off.
I can live without weed but why would I want to? It doesn't harm you and can give you amazing physical/emotional sensations you'd never be able to achieve sober. Plus it smells so good.