No legs. I can just imagine my nose itching or something and not having arms. Or being hungry/thirsty and nobody available to help me eat. Or a fly or mosquito getting in the house, buzzing around your head and you can't do ****. Or having to go to the bathroom and can't pull my bottoms off. FML that sounds miserable.
No legs. You can get mechanical/prosthetic ones, and if not, you can just ride in a wheelchair.
Without hands, you lose out on so many things that life would be totally altered forever. No legs would also alter things, but it wouldn't have as big of an effect.