Radioactive had chart life before Mirrors, Get Lucky, JGMAR, etc. and it's still in the top 5 in its 52nd week on the Hot 100. I think it'll end up joining TS and BL on Billboard's Year-End list.
As huge as "Radioactive" is in the US, it hasn't had the same amount of impact on other charts and therefore don't think it would be enough for top three. Last years top three, "Call Me Maybe", "Somebody That I Used to Know" and "We Are Young" hit #1 on pretty much nearly every important market. "Radioactive" didn't even reach top ten in the UK.