• a larger head to accommodate a larger brain
• larger nostrils for easier breathing in off-planet environments
• denser hair to contain heat loss from a larger head
• eyes getting larger, as attempts to colonize Earth’s solar system and beyond see people living in dimmer environments farther away from a sun
• skin becoming more pigmented to lessen the damage from harmful UV radiation
I honestly doubt things this radical, like eyes the size of baseballs and giant noses. I personally don't think science is yet able to accurately predict evolution that far into the future.
