The one that holds the Guiness World Record for going #1 in the most amount of countries, which also propelled its parent album to sell over 10 million copies worldwide without any kind of re-release and no promo for subsequent singles.
The one that spent 15 weeks at #1 WW, immediately followed by another 7 weeks at #1 by the second single from that album all without the support of USA.
It's Madonna's gigantic come-back single and reinforced her as a HUGE force in pop music.
It was one of the only pure dance-pop songs to go Top 10 in America during the mid 00s, where urban music totally dominated and threatened to get rid of dance-pop forever.