I hope not, but hope means very little in situations like that. I'm almost willing to bet that we will see the horrors of a nuclear detonation in our lifetimes.
A nuclear detonation is more or less likely to happen in our lifetime. North Korea and Iran both have developed technologies to obtain and launch nuclear missiles. North Korea has even gone as far as claim that they can reach U.S. targets.
The doomsday clock is current at 5 minutes to midnight.
It has been getting closer to midnight since the end of the cold war. Based on this fact, as well as the current political climate I think that I am going to say that it is more than likely.
Honestly, no. Using them doesn't accomplish anything. The point of having them is basically to be on the same playing field as the countries that have them