My personal favorite will always be the Vagina Monologue: Debra Wilson, Alex Borstein, Nicole Sullivan and Mo Collins.
Also the skits of Stefani Weir's Angela Wright.
This reminded me of this one which I think about all the time When she suggests the old lady might be blind so Angela throws an inflatable beach ball at her, and when the old lady hits it back Angela runs across the street yelling "She's not blind!"
When they try to help a disabled lady out of the pool she fell into but then they all end up stuck in it