I don't think so. Even 4 Minutes couldn't do it and neither could Give Me All Your Luvin' despite all of the hype and massive Superbowl promotion.

Its been a decade...

No, unfortunatly no one is here for Madonna any more, even though the quality of new music isn't even bad

She did collab with Britney, and that wasn't a hit. It didn't even go top 20.

Because Britney was blacklisted by radio at that time.

I don't think Madonna will have a US #1 unlike she pulls a "feat. Lady Gaga" stunt but she might have a massive worldwide single again. I just feel it.

I know that, but Toxic (#9) and Everytime (#15) were hits.

You tryna kill your fave sis....

Off topic but how was Britney blacklisted in 2003?

Not impossible, but probably not. Not off MDNA anyway, Gang Bang will be top 10 i reckon

Not with the streaming rule in effect; she'd have to open with 600k on the single's debut week or it would have to be really, really good and become a huge radio & digital hit..

I honestly think she could have if Girl Gone Wild had been released FIRST.

Absolutely no. I can't see a Top10 hit either.
If she does some major promo, she could, but not with this record.

With Payola another top 10 again perhaps.

If Madonna did die, hopefully her record label would release a posthumous ballad/masterpiece,