I would like a sort of more remote/wild terrain to explore, rather than numerous cities and thriving metropolis' like the past two gens. An ideal locale would be an Africa-based region, with huge deserts, savannahs, jungles to explore, with Gym's hidden in the middle of nowhere. This would also give a lot more chances to go back to basics with the designs, I love most of the ones I'm about name, but a Candle, Dishwasher, Chandelie and a Key Pokemon just aren't the tea anymore.
Give me my Fire Jaguar starter, Water Hippo starter and Grass Gazelle.