If you think about, though, Lois never really gets screen-time. I hope it's not her because I like her character, but it's the most feasible at the moment.
Whoever dies will be brought back after like 4 episodes. It will probably be Lois, Peter gets a new wife, but what do you know Lois is not dead! She comes back.
I hope it's Chris. He's just there.
Meg is the family toilet and they wouldn't kill her off. Plus her voice parts aren't that big anyway. Also Mila has a good relationship with Seth.
It could also mean Quagmire, or one of either's parents
The tweet CLEARLY says a Griffin will be killed. Not just any old member. Not saying it has to be one of the immediate family but lets remember, Lois' dad isn't a Griffin, Quagmire isn't a Griffin, so on and so forth.
Callaghan starts the panel with a bang by revealing that one of the Griffins will be killed and replaced with a new character in Season 12. "It could be anyone, any one of our six main cast," he adds. It did not seem like he was joking, and the crowd didn't quite know what to think.
The actual full quote from the Comic-Con panel and not the simplified Tweet. So it's definitely not going to be Peters Mother or real dad.
Whoever dies will be brought back after like 4 episodes. It will probably be Lois, Peter gets a new wife, but what do you know Lois is not dead! She comes back.
They should kill Chris. He's the least interesting. BTW didn't South Park already do this with Kenny (kill him permanently, I know he dies every episode) but then they brought him back to life a few years later?