99. Gorillaz - "Feel Good Inc."
96. Lady Gaga - "Poker Face"
95. Mary J. Blige - "Family Affair"
93. Snoop Dogg - "Drop It Like It's Hot"
86. Aaliyah - "Try Again"
84. Clipse - "Grindin'"
82. Jay-Z - "Dirt Off Your Shoulder"
80. Phoenix - "1901"
77. Dixie Chicks - "Not Ready To Make Nice"
76. Madonna - "Hung Up"
75. Arcade Fire - "Rebellion (Lies)"
72. Kings Of Leon - "Use Somebody"
71. Justice - "D.A.N.C.E."
68. Coldplay - "Viva La Vida"
67. Wilco - "Jesus, Etc."
66. Madonna - "Music"
63. Lil Wayne - "A Milli"
62. Alicia Keys - "Fallin'"
61. Jet - "Are You Gonna Be My Girl"
60. Beyoncé - "Irreplaceable"
55. OutKast - "Ms. Jackson"
54. Coldplay - "The Scientist"
50. Beyoncé - "Single Ladies"
45. Kylie Minogue - "Can't Get You Out Of My Head"
44. Britney Spears - "Toxic"
42. Arcade Fire - "Wake Up"
41. LCD Soundsystem - "All My Friends"
40. Kelis - "Milkshake"
39. Modest Mouse - "Float On"
33. Daft Punk - "One More Time"
30. R. Kelly - "Ignition (Remix)"
29. Kanye West - "Gold Digger"
26. Coldplay - "Clocks"
25. Missy Elliott - "Work It"
23. Rihanna - "Umbrella"
22. Amerie - "1 Thing"
21. OutKast - "B.O.B."
20. Justin Timberlake - "Cry Me A River"
19. Kanye West - "Jesus Walks"
18. Kelly Clarkson - "Since U Been Gone"
14. Missy Elliott - "Get Ur Freak On"
13. 50 Cent - "In Da Club"
12. Eminem "Lose Yourself"
11. MGMT - "Time To Pretend"
8. Amy Winehouse - "Rehab"
10. Eminem - "Stan"
5. M.I.A. - "Paper Planes"
4. OutKast - "Hey Ya!"
3. Beyoncé - "Crazy In Love"
2. Jay-Z - "99 Problems"
1. Gnarls Barkley - "Crazy"