| Pos | Pos+ | Artist and Title | Days | Peak | Pts | Released |
| 1 | = | Far East Movement - Like a G6 (feat. Cataracs & Dev) | 70 | 1(10) | 1.173 | 4/13/10 |
| 2 | = | Bruno Mars - Just the Way You Are | 84 | 1(12) | 1.811 | 7/20/10 |
| 3 | = | Nelly - Just a Dream | 57 | 3 | 1.193 | 8/17/10 |
| 4 | = | Rihanna - Only Girl (In the World) | 29 | 1(8) | 0.719 | 9/13/10 |
| 5 | +1 | Flo Rida - Club Can't Handle Me (feat. David Guetta) [F... | 101 | 5 | 1.153 | 6/28/10 |
| 6 | -1 | Taylor Swift - Speak Now | 8 | 1(3) | 0.206 | 10/5/10 |
| 7 | +1 | Taio Cruz - Dynamite | 131 | 1(6) | 2.732 | 6/1/10 |
| 8 | -1 | Usher - DJ Got Us Fallin' In Love (feat. Pitbull) | 91 | 2 | 1.633 | 6/25/10 |
| 9 | = | Katy Perry - Teenage Dream | 81 | 1(16) | 1.931 | 7/23/10 |
| 10 | = | Kanye West - Runaway (feat. Pusha T) | 9 | 2 | 0.164 | 10/4/10 |
| 11 | NEW | Taylor Swift - Back to December | 1 | 11 | 0.011 | 10/12/10 |
| 12 | -1 | Trey Songz - Bottoms Up (feat. Nicki Minaj) | 28 | 11 | 0.268 | 9/14/10 |
| 13 | = | Cee Lo Green - F**k You | 26 | 12 | 0.210 | 9/14/10 |
| 14 | +1 | Neon Trees - Animal | 131 | 14 | 0.703 | 3/16/10 |
| 15 | -3 | Ke$ha - Take It Off | 84 | 6 | 0.997 | 1/5/10 |
| 16 | -2 | Taylor Swift - Mine | 69 | 1(7) | 0.953 | 8/4/10 |
| 17 | -1 | Eminem - Love the Way You Lie (feat. Rihanna) | 114 | 1(33) | 2.708 | 6/21/10 |
| 18 | +2 | The Ready Set - Love Like Woe | 78 | 18 | 0.405 | 6/14/10 |
| 19 | = | Jay Sean - 2012 (It Ain't the End) [feat. Nicki Minaj] | 70 | 17 | 0.438 | 8/3/10 |
| 20 | +10 | P!nk - Raise Your Glass | 5 | 20 | 0.033 | 10/6/10 |
| 21 | -3 | B.o.B - Magic (feat. Rivers Cuomo) | 120 | 6 | 1.175 | 4/27/10 |
| 22 | -5 | Enrique Iglesias - I Like It (feat. Pitbull) | 131 | 3 | 2.017 | 5/3/10 |
| 23 | -2 | Pitbull - Hey Baby (Drop It to the Floor) [feat. T-Pain... | 14 | 16 | 0.108 | 9/14/10 |
| 24 | +1 | Yolanda Be Cool & Dcup - We No Speak Americano | 33 | 22 | 0.231 | 7/20/10 |
| 25 | -1 | Lil Wayne & Drake - Right Above It | 14 | 22 | 0.094 | 9/27/10 |
| 26 | = | The Band Perry - If I Die Young | 10 | 24 | 0.068 | 4/13/10 |
| 27 | = | Sean Kingston - Letting Go (Dutty Love) [feat. Nicki Mi... | 70 | 14 | 0.448 | 8/13/10 |
| 28 | -6 | Sugarland - Stuck Like Glue | 80 | 10 | 0.678 | 7/23/10 |
| 29 | -6 | OneRepublic - Secrets | 110 | 17 | 0.711 | 11/17/09 |
| 30 | -1 | Waka Flocka Flame - No Hands (feat. Roscoe Dash and Wal... | 35 | 14 | 0.214 | 9/6/10 |
| 31 | -3 | Eminem - Not Afraid | 131 | 5 | 1.455 | 6/21/10 |
| 32 | +2 | will.i.am & Nicki Minaj - Check It Out | 35 | 32 | 0.175 | 9/3/10 |
| 33 | +2 | Bruno Mars - Grenade | 7 | 33 | 0.029 | 10/5/10 |
| 34 | -3 | Usher - Hot Tottie (feat. Jay-Z) | 49 | 17 | 0.286 | 8/24/10 |
| 35 | +2 | Chris Brown - Deuces (feat. Tyga & Kevin McCall) | 104 | 31 | 0.448 | 6/29/10 |
| 36 | = | Mike Posner - Cooler Than Me (Single Mix) | 131 | 4 | 1.870 | 4/19/10 |
| 37 | -5 | Glee Cast - I Want To Hold Your Hand (Glee Cast Version... | 7 | 8 | 0.078 | 10/5/10 |
| 38 | -5 | Katy Perry - California Gurls (feat. Snoop Dogg) | 131 | 1(29) | 2.473 | 5/7/10 |
| 39 | -1 | Maroon 5 - Misery | 21 | 13 | 0.133 | 9/21/10 |
| 40 | +5 | Mike Posner - Please Don't Go | 12 | 40 | 0.110 | 8/10/10 |
| 41 | = | Lil Wayne & Drake - Gonerrhea | 15 | 6 | 0.162 | 9/27/10 |
| 42 | -2 | Adam Lambert - If I Had You | 107 | 24 | 0.550 | 11/20/09 |
| 43 | -1 | Sara Bareilles - King of Anything | 35 | 16 | 0.182 | 9/7/10 |
| 44 | -5 | Bruno Mars - Just the Way You Are | 7 | 39 | 0.029 | 10/5/10 |
| 45 | -1 | Jason Derülo - Ridin' Solo | 131 | 4 | 1.568 | 2/26/10 |
| 46 | = | Cali Swag District - Teach Me How to Dougie | 112 | 28 | 0.528 | 4/6/10 |
| 47 | +1 | Mumford & Sons - Little Lion Man | 66 | 41 | 0.320 | 2/16/10 |
| 48 | +4 | Jason Aldean - My Kinda Party | 49 | 23 | 0.222 | 8/24/10 |
| 49 | +1 | Paramore - The Only Exception | 131 | 20 | 0.715 | 9/29/09 |
| 50 | +3 | Eminem - No Love (feat. Lil Wayne) | 56 | 8 | 0.383 | 6/21/10 |
| 51 | +18 | Wiz Khalifa - Black and Yellow | 19 | 46 | 0.082 | 9/14/10 |
| 52 | -9 | Glee Cast - One of Us (Glee Cast Version) | 7 | 6 | 0.076 | 10/5/10 |
| 53 | -6 | Selena Gomez & The Scene - A Year Without Rain | 21 | 19 | 0.096 | 9/21/10 |
| 54 | = | Biz Markie - Just a Friend | 7 | 40 | 0.042 | 6/30/94 |
| 55 | +2 | Zac Brown Band - As She's Walking Away (feat. Alan Jack... | 20 | 46 | 0.081 | 9/20/10 |
| 56 | +3 | Drake, T.I. & Swizz Beatz - Fancy | 44 | 30 | 0.262 | 6/15/10 |
| 57 | -8 | Glee Cast - Only the Good Die Young (Glee Cast Version) | 7 | 10 | 0.059 | 10/5/10 |
| 58 | -3 | Train - Hey, Soul Sister | 131 | 14 | 0.817 | 8/7/09 |
| 59 | -1 | Daughtry - September | 53 | 56 | 0.235 | 7/10/09 |
| 60 | -9 | Bruno Mars - The Lazy Song | 7 | 31 | 0.036 | 10/5/10 |
| 61 | +1 | A Rocket to the Moon - Like We Used to | 7 | 48 | 0.193 | 10/12/09 |
| 62 | -2 | DJ Khaled - All I Do Is Win (feat. T-Pain, Ludacris, Sn... | 131 | 26 | 0.588 | 2/9/10 |
| 63 | -7 | B.o.B - Airplanes (feat. Hayley Williams of Paramore) | 131 | 2 | 1.719 | 4/13/10 |
| 64 | +12 | Darius Rucker - Come Back Song | 70 | 35 | 0.273 | 7/13/10 |
| 65 | -1 | Vanilla Ice - Ice Ice Baby (Edit) | 7 | 62 | 0.025 | 3/12/01 |
| 66 | +6 | Florence + The Machine - Dog Days Are Over | 50 | 3 | 0.349 | 7/5/09 |
| 67 | -6 | Auburn - La, La, La (feat. Iyaz) | 89 | 30 | 0.455 | 6/1/10 |
| 68 | -5 | Usher - OMG (feat. will.i.am) | 131 | 2 | 1.514 | 3/30/10 |
| 69 | -2 | Train - If It's Love | 121 | 34 | 0.516 | 10/26/09 |
| 70 | -2 | Plain White T's - Rhythm of Love | 53 | 46 | 0.186 | 8/10/10 |
| 71 | -5 | Kenny Chesney - The Boys of Fall | 11 | 49 | 0.043 | 9/28/10 |
| 72 | +2 | Linkin Park - The Catalyst | 28 | 15 | 0.141 | 9/14/10 |
| 73 | +4 | Rodney Atkins - Farmer's Daughter | 88 | 59 | 0.283 | 6/29/10 |
| 74 | +126 | Miley Cyrus - Who Owns My Heart | 1 | 74 | 0.018 | 6/21/10 |
| 75 | -2 | Shakira - Waka Waka (This Time for Africa) [The Officia... | 126 | 19 | 0.565 | 5/11/10 |
| 76 | +2 | Taio Cruz & Ludacris - Break Your Heart | 128 | 11 | 0.809 | 6/1/10 |
| 77 | +8 | Jesse McCartney - Shake | 8 | 52 | 0.053 | 9/21/10 |
| 78 | -13 | Glee Cast - Losing My Religion (Glee Cast Version) | 7 | 13 | 0.047 | 10/5/10 |
| 79 | = | Travie McCoy - Billionaire (feat. Bruno Mars) | 131 | 4 | 1.395 | 3/9/10 |
| 80 | +24 | Kid Cudi - Soundtrack 2 My Life | 16 | 72 | 0.160 | 9/15/09 |
| 81 | -11 | Glee Cast - Toxic (Glee Cast Version) | 15 | 1(1) | 0.158 | 9/28/10 |
| 82 | +12 | Kid Cudi - Erase Me (feat. Kanye West) | 49 | 4 | 0.293 | 8/24/10 |
| 83 | -8 | The Black Eyed Peas - I Gotta Feeling | 131 | 31 | 0.517 | 6/9/09 |
| 84 | -13 | Glee Cast - Papa Can You Hear Me? (Glee Cast Version) | 7 | 15 | 0.044 | 10/5/10 |
| 85 | +6 | Nicki Minaj - Right Thru Me | 14 | 35 | 0.050 | 9/24/10 |
| 86 | -2 | Eric Church - Smoke a Little Smoke | 34 | 71 | 0.137 | 3/24/09 |
| 87 | -7 | The Proclaimers - I'm Gonna Be (500 Miles) | 7 | 58 | 0.028 | 12/31/87 |
| 88 | +7 | Kanye West - Power | 86 | 9 | 0.416 | 7/1/10 |
| 89 | -7 | Big Time Rush - Til I Forget About You | 9 | 66 | 0.045 | 9/21/10 |
| 90 | -7 | Eminem - Not Afraid | 100 | 54 | 0.359 | 6/21/10 |
| 91 | +10 | Edward Maya & Vika Jigulina - Stereo Love | 2 | 91 | 0.124 | 2/2/10 |
| 92 | -4 | Coldplay - Viva la Vida | 5 | 84 | 0.061 | 6/11/08 |
| 93 | -4 | Cee Lo Green - Forget You | 4 | 89 | 0.051 | 9/14/10 |
| 94 | -1 | Antoine Dodson & The Gregory Brothers - Bed Intruder So... | 66 | 29 | 0.261 | 8/10/10 |
| 95 | +8 | Edward Sharpe & The Magnetic Zeros - Home | 2 | 91 | 0.110 | 6/29/10 |
| 96 | +10 | Enrique Iglesias - I Like It (feat. Pitbull) | 17 | 50 | 0.207 | 7/6/10 |
| 97 | -5 | Lil Wayne & Nicki Minaj - What's Wrong With Them | 15 | 12 | 0.087 | 9/27/10 |
| 98 | -8 | La Roux - Bulletproof | 129 | 9 | 0.874 | 9/22/09 |
| 99 | -12 | Eminem - Love the Way You Lie (feat. Rihanna) | 109 | 26 | 0.494 | 6/21/10 |
| 100 | +9 | Miley Cyrus - Can't Be Tamed | 63 | 12 | 0.533 | 6/21/10 |
| 101 | -5 | YG - Toot It and Boot It | 6 | 87 | 0.160 | 6/8/10 |
| 102 | -16 | Justin Bieber - U Smile | 15 | 62 | 0.139 | 3/23/10 |
| 104 | -6 | Soulja Boy Tell'em - Pretty Boy Swag | 93 | 38 | 0.421 | 6/8/10 |
| 105 | -24 | John Lennon - Imagine | 2 | 64 | 0.014 | 10/1/10 |
| 106 | -7 | Justin Bieber & Ludacris - Baby | 123 | 27 | 0.502 | 3/23/10 |
| 108 | +14 | Eminem - Lose Yourself | -- | 108 | 0.241 | 10/29/02 |
| 110 | NEW | Glee Cast - Don't Go Breaking My Heart (Glee Cast Versi... | -- | 110 | 0.002 | 10/12/10 |
| 120 | -23 | Glee Cast - Bridge Over Troubled Water (Glee Cast Versi... | 6 | 16 | 0.038 | 10/5/10 |
| 122 | NEW | Glee Cast - Lucky (Glee Cast Version) | -- | 122 | 0.002 | 10/12/10 |
| 135 | NEW | Glee Cast - River Deep, Mountain High (Glee Cast Versio... | -- | 135 | 0.002 | 10/12/10 |
| 136 | +6 | will.i.am & Nicki Minaj - Check It Out (Main Radio Mix) | -- | 136 | 0.033 | 9/8/10 |
| 139 | NEW | Glee Cast - Happy Days Are Here Again / Get Happy (Glee... | -- | 139 | 0.002 | 10/12/10 |
| 145 | +57 | Natasha Bedingfield - Strip Me | -- | 123 | 0.033 | 9/21/10 |
| 149 | +48 | Christina Perri - Jar of Hearts | -- | 112 | 0.103 | 7/27/10 |
| 151 | +24 | Jet - Are You Gonna Be My Girl | -- | 151 | 0.023 | 9/16/03 |
| 152 | +11 | David Guetta - Memories | -- | 152 | 0.049 | 3/29/10 |
| 156 | +13 | Ben E. King - Stand By Me | -- | 156 | 0.010 | 3/14/06 |
| 171 | NEW | Glee Cast - Le Jazz Hot (Glee Cast Version) | -- | 171 | 0.002 | 10/12/10 |
| 175 | NEW | Glee Cast - Sing! (Glee Cast Version) | -- | 175 | 0.001 | 10/12/10 |
| 178 | NEW | Nelly, Akon & T-Pain - Move That Body (feat. T-Pain & A... | -- | 178 | 0.001 | 10/12/10 |
| 189 | NEW | Big Time Rush - Boyfriend | -- | 189 | 0.001 | 10/11/10 |
| 202 | NEW | Big Time Rush - Count On You (feat. Jordin Sparks) | -- | 202 | 0.001 | 10/11/10 |
| 234 | NEW | Sugarland - Little Miss | -- | 234 | 0.001 | 10/12/10 |
| 236 | +153 | Grits - Ooh Ahh (My Life Be Like)[feat. tobyMac] | -- | 236 | 0.006 | 8/27/02 |
| 243 | +212 | Broken Bells - The High Road | -- | 199 | 0.119 | 3/5/10 |
| 255 | +90 | Katy Perry - Firework | 3 | 52 | 0.034 | 8/24/10 |
| 277 | NEW | Big Time Rush - Til I Forget About You | -- | 277 | 0.001 | 10/11/10 |
| 311 | NEW | My Chemical Romance - The Only Hope for Me Is You | -- | 311 | 0.001 | 10/12/10 |
| 433 | NEW | Keri Hilson - Pretty Girl Rock | -- | 433 | 0.001 | 10/12/10 |
| 437 | +438 | Kanye West - Amazing (feat. Young Jeezy) | -- | 129 | 0.012 | 11/24/08 |
| 445 | +114 | Darius Rucker - Alright | -- | 347 | 0.023 | 9/16/08 |
| 496 | NEW | Megan & Liz Feat. Memphis High - Need Your Poison | -- | 496 | 0.001 | 10/11/10 |
| 501 | +271 | Chappo - Come Home | -- | 501 | 0.001 | 4/23/10 |
| 502 | +471 | Queen - Bohemian Rhapsody | -- | 148 | 0.108 | 3/9/92 |
| 508 | NEW | Josh Groban - Voce Existe Em Mim | -- | 508 | 0.000 | 10/12/10 |
| 528 | +171 | Kanye West - Flashing Lights | -- | 155 | 0.096 | 9/11/07 |
| 535 | +134 | Everclear - Father of Mine | -- | 503 | 0.003 | 9/25/97 |
| 536 | +196 | Rock On - Born Free (made famous by Kid Rock) | -- | 510 | 0.002 | 9/13/10 |
| 543 | +210 | Michael Bublé - Home | -- | 351 | 0.059 | 2/7/05 |
| 555 | +218 | GG - Bottoms Up (Street Mix) | -- | 555 | 0.001 | 10/1/10 |
| 574 | NEW | Miranda Cosgrove - Shakespeare | -- | 574 | 0.000 | 4/26/10 |
| 588 | NEW | Lil Wayne, Jae Millz, Gudda Gudda & Tyga - YM Banger | -- | 588 | 0.000 | 10/12/10 |
| 607 | +218 | Yellowcard - Only One | -- | 607 | 0.002 | 7/10/03 |
| 633 | NEW | Big Time Rush - Nothing Even Matters | -- | 633 | 0.000 | 10/11/10 |
| 666 | NEW | Mariah Carey - Oh Santa! | -- | 666 | 0.000 | 10/12/10 |
| 671 | NEW | Far East Movement & Ryan Tedder - Rocketeer | -- | 671 | 0.000 | 10/9/10 |
