This could be Usher's year. I can totally see him get nominated (possibly winning) in most of these categories:
Album of the Year Raymond v. Raymond
Record of the Year OMG with will.i.am
Song of the Year OMG with will.i.am
Best Pop Collaboration With Vocals OMG with will.i.am
Best Pop Collaboration With Vocals DJ Got Us Fallin' In Love with Pitbull
Best Dance Recording OMG with will.i.am
Best Dance Recording DJ Got Us Fallin' In Love with Pitbull
Best Male R&B Vocal Performance There Goes My Baby
Best R&B Song There Goes My Baby
Best Contemporary R&B Album Raymond v. Raymond
Best Rap/Sung Collaboration Lil Freak with Nicki Minaj
Best Rap/Sung Collaboration Hot Tottie with Jay-Z
Album of the Year and Record of the Year are a long shot though.
He has Best Male R&B Vocal Performance on lock and most likely Best R&B Song and Best Contemporary R&B Album too.
Song of the Year, Best Pop Collaboration With Vocals and Best Rap/Sung Collaboration could also go to him, the competition is extremely weak this year.
His nominations and wins so far:
Best Male R&B Vocal Performance (7 nominations, 2 wins)
Best R&B Performance by a Duo or Group With Vocals (2 nominations, 1 win)
Best Rap/Sung Collaboration (1 win)
Best Contemporary R&B Album (1 win)
Best R&B Song (2 nominations)
Album of the Year (1 nomination)
Record of the Year for (1 nomination)