I'll be predictable and say Tim Burton. But then HBC would end up being the bride and Johnny Depp as Dr Frankenstein.
I liked Big Eyes just fine but Tim Burton has lost it. I want someone like Matt Reeves or J.A. Bayona or maybe the Russo Brothers. Anyway it's a great role for her cuz she'll be wearing heavy makeup/wigs, hiding the fact that her weight and age are only a few digits apart.