| Pos | Pos+ | Artist and Title | Days | Peak | Pts | Released |
| 1 | = | Bruno Mars - Grenade | 87 | 1(12) | 1.384 | 10/5/10 |
| 2 | = | Katy Perry - Firework | 77 | 1(22) | 1.809 | 8/24/10 |
| 3 | = | Ke$ha - We R Who We R | 67 | 1(15) | 1.714 | 10/22/10 |
| 4 | = | Rihanna & Drake - What's My Name? | 45 | 3 | 0.886 | 11/16/10 |
| 5 | = | The Black Eyed Peas - The Time (Dirty Bit) | 31 | 3 | 0.645 | 11/30/10 |
| 6 | +1 | Enrique Iglesias - Tonight (I'm Lovin' You) [feat. Luda... | 39 | 4 | 0.347 | 1/11/11 |
| 7 | +2 | P!nk - Raise Your Glass | 85 | 3 | 1.485 | 10/6/10 |
| 8 | -2 | Trey Songz - Bottoms Up (feat. Nicki Minaj) | 108 | 5 | 1.456 | 9/14/10 |
| 9 | -1 | Wiz Khalifa - Black and Yellow | 10 | 7 | 0.141 | 12/21/10 |
| 10 | = | Nelly - Just a Dream | 137 | 2 | 2.399 | 8/17/10 |
| 11 | +1 | Taio Cruz - Dynamite | 211 | 1(6) | 3.492 | 6/1/10 |
| 12 | +1 | Rihanna - Only Girl (In the World) | 23 | 12 | 0.224 | 11/16/10 |
| 13 | -2 | Bruno Mars - Just the Way You Are | 164 | 1(12) | 2.955 | 7/20/10 |
| 14 | +1 | Lil Wayne - 6 Foot 7 Foot (feat. Cory Gunz) | 15 | 1(5) | 0.341 | 12/16/10 |
| 15 | -1 | Far East Movement, The Cataracs & Dev - Like a G6 | 150 | 1(16) | 2.567 | 10/9/10 |
| 16 | = | Waka Flocka Flame - No Hands (feat. Roscoe Dash & Wale) | 115 | 14 | 0.829 | 9/6/10 |
| 17 | +1 | Diddy - Dirty Money & Skylar Grey - Coming Home | 17 | 8 | 0.178 | 12/14/10 |
| 18 | -1 | Usher - DJ Got Us Fallin' In Love (feat. Pitbull) | 171 | 2 | 2.365 | 6/25/10 |
| 19 | = | Mike Posner - Please Don't Go | 91 | 12 | 0.728 | 8/10/10 |
| 20 | +2 | Chris Brown - Yeah 3X | 67 | 12 | 0.400 | 10/25/10 |
| 21 | = | Taylor Swift - Back to December | 64 | 21 | 0.321 | 10/25/10 |
| 22 | +3 | Edward Maya & Vika Jigulina - Stereo Love | 82 | 12 | 0.556 | 2/2/10 |
| 23 | -3 | Willow - Whip My Hair | 67 | 2 | 0.713 | 10/26/10 |
| 24 | -1 | Neon Trees - Animal | 211 | 12 | 1.290 | 3/16/10 |
| 25 | +5 | Pitbull - Hey Baby (Drop It to the Floor) [feat. T-Pain... | 94 | 16 | 0.581 | 9/17/10 |
| 26 | +2 | Flo Rida - Club Can't Handle Me (feat. David Guetta) [F... | 181 | 5 | 1.857 | 6/28/10 |
| 27 | -1 | Taylor Swift - Mine | 67 | 16 | 0.331 | 10/25/10 |
| 28 | -4 | The Band Perry - If I Die Young | 79 | 14 | 0.552 | 10/12/10 |
| 29 | +2 | Sugarland - Stuck Like Glue | 64 | 9 | 0.426 | 10/19/10 |
| 30 | -1 | OneRepublic - Secrets | 190 | 16 | 1.224 | 11/17/09 |
| 31 | +3 | Cee Lo Green - F**k You | 105 | 6 | 0.880 | 9/14/10 |
| 32 | -5 | The Ready Set - Love Like Woe | 158 | 14 | 0.910 | 6/14/10 |
| 33 | -1 | Lil Wayne & Drake - Right Above It | 43 | 29 | 0.204 | 11/16/10 |
| 34 | +1 | Katy Perry - California Gurls (feat. Snoop Dogg) | 19 | 34 | 0.140 | 8/24/10 |
| 35 | +3 | Far East Movement & Ryan Tedder - Rocketeer | 21 | 33 | 0.142 | 10/9/10 |
| 36 | +1 | Christina Perri - Jar of Hearts | 77 | 27 | 0.456 | 7/27/10 |
| 37 | -4 | Katy Perry - Teenage Dream | 161 | 1(16) | 2.489 | 7/23/10 |
| 38 | -2 | The Lonely Island - I Just Had Sex (feat. Akon) | 12 | 7 | 0.118 | 12/19/10 |
| 39 | +1 | Eminem - No Love (feat. Lil Wayne) | 136 | 8 | 0.756 | 6/21/10 |
| 40 | +3 | Victorious Cast - Freak the Freak Out (feat. Victoria J... | 33 | 13 | 0.160 | 11/22/10 |
| 41 | = | Eminem - Love the Way You Lie (feat. Rihanna) | 194 | 1(33) | 3.126 | 6/21/10 |
| 42 | -3 | B.o.B - Magic (feat. Rivers Cuomo) | 181 | 6 | 1.472 | 4/27/10 |
| 43 | +1 | Jason Aldean - My Kinda Party | 58 | 33 | 0.231 | 11/2/10 |
| 44 | +3 | Kenny Chesney - Somewhere With You | 59 | 31 | 0.287 | 9/28/10 |
| 45 | +9 | The Black Eyed Peas - I Gotta Feeling | 208 | 31 | 0.762 | 6/9/09 |
| 46 | = | Tim McGraw - Felt Good On My Lips | 30 | 46 | 0.122 | 11/30/10 |
| 47 | -5 | Keri Hilson - Pretty Girl Rock | 9 | 28 | 0.049 | 12/21/10 |
| 48 | +1 | Jason Aldean - Don't You Wanna Stay (with Kelly Clarkso... | 58 | 18 | 0.245 | 11/2/10 |
| 49 | +3 | Florence + The Machine - Dog Days Are Over | 129 | 3 | 0.751 | 7/5/09 |
| 50 | -5 | Ke$ha - Take It Off | 156 | 6 | 1.363 | 1/4/09 |
| 51 | +4 | Flo Rida - Who Dat Girl (feat. Akon) | 31 | 22 | 0.133 | 11/24/10 |
| 52 | -4 | Eminem - Not Afraid | 199 | 5 | 1.726 | 6/21/10 |
| 53 | -2 | Nicki Minaj - Right Thru Me | 36 | 34 | 0.152 | 11/22/10 |
| 54 | -4 | Mike Posner - Cooler Than Me (Single Mix) | 187 | 4 | 2.122 | 4/19/10 |
| 55 | -2 | P!nk - Raise Your Glass | 67 | 39 | 0.261 | 10/6/10 |
| 56 | +2 | Sara Bareilles - King of Anything | 115 | 16 | 0.483 | 9/7/10 |
| 57 | = | Train - Hey, Soul Sister | 199 | 14 | 1.076 | 8/7/09 |
| 58 | -2 | Enrique Iglesias - I Like It (feat. Pitbull) | 211 | 3 | 2.393 | 5/3/10 |
| 59 | +3 | Plain White T's - Rhythm of Love | 22 | 54 | 0.081 | 12/7/10 |
| 60 | +8 | Mumford & Sons - Little Lion Man | 146 | 38 | 0.628 | 2/16/10 |
| 61 | -2 | Ke$ha - Tik Tok | 122 | 28 | 0.636 | 1/4/09 |
| 62 | +7 | Jeremih & 50 Cent - Down On Me (feat. 50 Cent) | 52 | 33 | 0.244 | 9/28/10 |
| 63 | +4 | Yolanda Be Cool & Dcup - We No Speak Americano | 113 | 16 | 0.678 | 7/20/10 |
| 64 | -1 | Michael Jackson - Hold My Hand (Duet with Akon) | 17 | 21 | 0.091 | 12/14/10 |
| 65 | +1 | Katy Perry - Teenage Dream | 31 | 16 | 0.306 | 8/24/10 |
| 66 | +12 | Big Time Rush - Big Night | 2 | 66 | 0.033 | 10/11/10 |
| 67 | -2 | Blake Shelton - Who Are You When I'm Not Looking | 55 | 58 | 0.233 | 8/6/10 |
| 68 | +6 | Lady Antebellum - Need You Now | 81 | 38 | 0.371 | 1/26/10 |
| 69 | -8 | Cali Swag District - Teach Me How to Dougie | 16 | 56 | 0.072 | 4/6/10 |
| 70 | -10 | Jason Derülo - Ridin' Solo | 169 | 4 | 1.756 | 2/26/10 |
| 71 | +1 | Dr. Dre - Kush (feat. Snoop Dogg & Akon) | 43 | 12 | 0.248 | 11/18/10 |
| 72 | -8 | Taio Cruz & Travie McCoy - Higher (feat. Travie McCoy) | 10 | 21 | 0.054 | 12/20/10 |
| 73 | +2 | Bruno Mars - Marry You | 41 | 37 | 0.161 | 10/5/10 |
| 74 | -3 | Justin Bieber & Ludacris - Baby | 134 | 27 | 0.659 | 3/23/10 |
| 75 | -5 | B.o.B - Airplanes (feat. Hayley Williams) | 161 | 2 | 1.908 | 4/13/10 |
| 76 | +3 | Maroon 5 - Misery | 58 | 13 | 0.318 | 9/21/10 |
| 77 | +3 | Zac Brown Band - As She's Walking Away (feat. Alan Jack... | 99 | 29 | 0.375 | 9/20/10 |
| 78 | -5 | Sean Kingston - Letting Go (Dutty Love) [feat. Nicki Mi... | 146 | 14 | 0.805 | 8/3/10 |
| 79 | -2 | T.I. - That's All She Wrote (feat. Eminem) | 25 | 4 | 0.252 | 12/7/10 |
| 80 | -4 | Usher - OMG (feat. will.i.am) | 164 | 2 | 1.704 | 3/30/10 |
| 81 | = | Taio Cruz & Ludacris - Break Your Heart | 143 | 11 | 0.945 | 6/1/10 |
| 82 | +8 | Bruno Mars - Just the Way You Are | 12 | 39 | 0.107 | 10/5/10 |
| 83 | -1 | Birdman & Lil Wayne - Fire Flame (feat. Lil Wayne) | 30 | 54 | 0.110 | 11/22/10 |
| 84 | +4 | Enrique Iglesias - Tonight (I'm F**kin' You) [feat. Lud... | 39 | 13 | 0.261 | 1/11/11 |
| 85 | +2 | Thompson Square - Are You Gonna Kiss Me or Not | 17 | 80 | 0.156 | 8/3/10 |
| 86 | +9 | Usher - More | 10 | 73 | 0.051 | 3/30/10 |
| 87 | +4 | Rick Ross - Aston Martin Music (feat. Drake & Chrisette... | 77 | 32 | 0.313 | 7/20/10 |
| 88 | -4 | Chris Brown - Deuces (feat. Tyga & Kevin McCall) | 160 | 31 | 0.685 | 6/29/10 |
| 89 | -6 | Troop 41 - Do The John Wall | 11 | 67 | 0.034 | 11/19/10 |
| 90 | +2 | Lady GaGa - Poker Face | 123 | 55 | 0.526 | 10/28/08 |
| 91 | -5 | Ke$ha - Your Love Is My Drug | 120 | 5 | 1.104 | 1/4/09 |
| 92 | +6 | DJ Khaled - All I Do Is Win (feat. T-Pain, Ludacris, Sn... | 168 | 26 | 0.788 | 2/9/10 |
| 93 | = | Wiz Khalifa - Black and Yellow | 7 | 80 | 0.023 | 12/21/10 |
| 94 | +6 | Billy Currington - Let Me Down Easy | 16 | 72 | 0.143 | 9/21/10 |
| 95 | -10 | Selena Gomez & The Scene - A Year Without Rain | 50 | 19 | 0.252 | 9/21/10 |
| 96 | = | Drake, Kanye West, Lil Wayne & Eminem - Forever | 7 | 82 | 0.342 | 9/29/09 |
| 97 | +7 | Linkin Park - Waiting for the End | 19 | 63 | 0.226 | 9/14/10 |
| 98 | -9 | Rodney Atkins - Farmer's Daughter | 118 | 59 | 0.460 | 6/29/10 |
| 99 | -2 | Miranda Lambert - Only Prettier | 35 | 57 | 0.326 | 9/29/09 |
| 100 | -6 | Jesse McCartney - Shake | 71 | 47 | 0.297 | 9/21/10 |
| 107 | -8 | Lil Wayne & Eminem - Drop the World | 26 | 75 | 0.341 | 2/2/10 |
| 119 | +1 | Chris Brown - Yeah 3X | -- | 119 | 0.070 | 10/26/10 |
| 130 | +11 | Wiz Khalifa - Make It Hot | -- | 130 | 0.015 | 7/28/08 |
| 131 | +40 | Kanye West, Jay-Z, Rick Ross, Nicki Minaj & Bon Iver - ... | 5 | 90 | 0.080 | 11/22/10 |
| 145 | +42 | Mumford & Sons - The Cave | -- | 145 | 0.144 | 2/16/10 |
| 157 | +8 | Nickelback - How You Remind Me | -- | 157 | 0.029 | 9/10/01 |
| 290 | +83 | Fabolous - You Be Killin Em | -- | 240 | 0.046 | 8/31/10 |
| 302 | +77 | Michael Franti & Spearhead - Say Hey (I Love You) [feat... | 20 | 57 | 0.345 | 8/18/09 |
| 398 | +101 | Edward Sharpe & The Magnetic Zeros - Home | 6 | 71 | 0.205 | 7/27/10 |
| 423 | +146 | P!nk - F**kin' Perfect | 5 | 66 | 0.031 | 11/16/10 |
| 531 | +159 | OutKast - Hey Ya! (Radio Mix/Club Mix) | -- | 455 | 0.074 | 9/23/03 |
| 650 | +184 | Teena Marie - Square Biz | -- | 650 | 0.001 | 12/31/80 |
| 663 | +196 | Kings of Leon - Radioactive | 15 | 37 | 0.097 | 10/19/10 |
| 664 | +245 | House Of Pain - Jump Around | -- | 265 | 0.107 | 12/31/93 |
