| Pos | Pos+ | Artist and Title | Days | Peak | Pts | Released |
| 1 | = | Bruno Mars - Grenade | 110 | 1(25) | 2.115 | 10/5/10 |
| 2 | +1 | Pitbull - Hey Baby (Drop It to the Floor) [feat. T-Pain... | 117 | 2 | 0.839 | 9/17/10 |
| 3 | -1 | Britney Spears - Hold It Against Me | 13 | 1(10) | 0.432 | 1/11/11 |
| 4 | +2 | Katy Perry - Firework | 100 | 1(22) | 2.383 | 8/24/10 |
| 5 | -1 | Wiz Khalifa - Black and Yellow | 33 | 3 | 0.583 | 12/21/10 |
| 6 | -1 | Diddy - Dirty Money & Skylar Grey - Coming Home | 40 | 4 | 0.471 | 12/14/10 |
| 7 | +4 | P!nk - F**kin' Perfect | 21 | 7 | 0.143 | 11/16/10 |
| 8 | = | The Black Eyed Peas - The Time (Dirty Bit) | 54 | 3 | 1.124 | 11/30/10 |
| 9 | -2 | Enrique Iglesias - Tonight (I'm Lovin' You) [feat. Luda... | 62 | 4 | 0.808 | 1/30/11 |
| 10 | -1 | Ke$ha - We R Who We R | 90 | 1(15) | 2.150 | 10/22/10 |
| 11 | +1 | Far East Movement & Ryan Tedder - Rocketeer | 44 | 11 | 0.356 | 10/9/10 |
| 12 | -2 | Lil Wayne - 6 Foot 7 Foot (feat. Cory Gunz) | 38 | 1(5) | 0.673 | 12/16/10 |
| 13 | = | Rihanna & Drake - What's My Name? | 68 | 3 | 1.225 | 11/16/10 |
| 14 | +1 | Christina Perri - Jar of Hearts | 100 | 13 | 0.647 | 7/27/10 |
| 15 | +2 | Usher - More | 33 | 15 | 0.190 | 3/30/10 |
| 16 | -2 | Waka Flocka Flame - No Hands (feat. Roscoe Dash & Wale) | 138 | 12 | 1.057 | 9/6/10 |
| 17 | -1 | Edward Maya & Vika Jigulina - Stereo Love | 105 | 12 | 0.773 | 2/2/10 |
| 18 | +5 | Taio Cruz - Dynamite | 19 | 8 | 0.189 | 12/21/10 |
| 19 | +2 | P!nk - Raise Your Glass | 108 | 3 | 1.749 | 10/6/10 |
| 20 | -2 | Cee Lo Green - F**k You | 128 | 6 | 1.058 | 9/14/10 |
| 21 | +3 | Bruno Mars - Just the Way You Are | 187 | 1(12) | 3.144 | 7/20/10 |
| 22 | -3 | Chris Brown - Yeah 3X | 90 | 12 | 0.577 | 10/25/10 |
| 23 | -1 | The Script - For the First Time | 5 | 21 | 0.034 | 1/18/11 |
| 24 | +2 | Taio Cruz & Travie McCoy - Higher (Bonus Track) | 19 | 24 | 0.113 | 12/21/10 |
| 25 | -5 | Jeremih & 50 Cent - Down On Me (feat. 50 Cent) | 75 | 20 | 0.373 | 9/28/10 |
| 26 | +3 | Taylor Swift - Back to December | 87 | 21 | 0.474 | 10/25/10 |
| 27 | -2 | Flo Rida - Who Dat Girl (feat. Akon) | 54 | 22 | 0.270 | 11/24/10 |
| 28 | = | Jason Aldean - Don't You Wanna Stay (with Kelly Clarkso... | 81 | 18 | 0.374 | 11/2/10 |
| 29 | +2 | Far East Movement, The Cataracs & Dev - Like a G6 | 173 | 1(16) | 2.748 | 10/9/10 |
| 30 | -3 | Avril Lavigne - What the Hell | 12 | 2 | 0.196 | 1/7/11 |
| 31 | +1 | Rihanna - Only Girl (In the World) | 46 | 12 | 0.406 | 11/16/10 |
| 32 | -2 | Trey Songz - Bottoms Up (feat. Nicki Minaj) | 131 | 5 | 1.684 | 9/14/10 |
| 33 | +1 | Nelly - Just a Dream | 160 | 2 | 2.581 | 8/17/10 |
| 34 | -1 | Train - Marry Me | 53 | 24 | 0.292 | 10/26/09 |
| 35 | = | Usher - DJ Got Us Fallin' In Love (feat. Pitbull) | 194 | 2 | 2.517 | 6/25/10 |
| 36 | +1 | P!nk - F**kin' Perfect | 18 | 36 | 0.098 | 12/14/10 |
| 37 | +1 | Plain White T's - Rhythm of Love | 45 | 35 | 0.189 | 12/7/10 |
| 38 | -2 | Kenny Chesney - Somewhere With You | 82 | 31 | 0.406 | 9/28/10 |
| 39 | +1 | Keri Hilson - Pretty Girl Rock | 32 | 28 | 0.153 | 12/21/10 |
| 40 | +1 | Thompson Square - Are You Gonna Kiss Me or Not | 40 | 39 | 0.248 | 8/3/10 |
| 41 | +5 | OneRepublic - Secrets | 213 | 16 | 1.355 | 11/17/09 |
| 42 | +5 | Willow - Whip My Hair | 90 | 2 | 0.846 | 10/26/10 |
| 43 | -4 | The Lonely Island - I Just Had Sex (feat. Akon) | 35 | 7 | 0.250 | 12/19/10 |
| 44 | +6 | Sugarland - Stuck Like Glue | 87 | 9 | 0.542 | 10/19/10 |
| 45 | -1 | The Band Perry - If I Die Young | 102 | 14 | 0.676 | 10/12/10 |
| 46 | +6 | Neon Trees - Animal | 234 | 12 | 1.411 | 3/16/10 |
| 47 | -2 | Mike Posner - Please Don't Go | 114 | 12 | 0.870 | 8/10/10 |
| 48 | = | Tim McGraw - Felt Good On My Lips | 53 | 41 | 0.225 | 11/30/10 |
| 49 | -7 | Nicki Minaj & Drake - Moment 4 Life | 26 | 42 | 0.162 | 11/22/10 |
| 50 | -1 | Troop 41 - Do the John Wall | 34 | 48 | 0.119 | 11/19/10 |
| 51 | +2 | Florence + The Machine - Dog Days Are Over | 152 | 3 | 0.851 | 7/5/09 |
| 52 | +2 | Flo Rida - Club Can't Handle Me (feat. David Guetta) [F... | 204 | 5 | 1.971 | 6/28/10 |
| 53 | +8 | Adele - Rolling In the Deep | 29 | 33 | 0.147 | 11/30/10 |
| 54 | +1 | Wiz Khalifa - Black and Yellow | 30 | 54 | 0.099 | 12/21/10 |
| 55 | +23 | Victorious Cast - Freak the Freak Out (feat. Victoria J... | 56 | 13 | 0.259 | 11/22/10 |
| 56 | +19 | Justin Bieber - Never Say Never (feat. Jaden Smith) | 55 | 9 | 0.488 | 6/8/10 |
| 57 | +3 | Cee Lo Green - Forget You | 79 | 17 | 0.375 | 9/14/10 |
| 58 | +7 | The Black Eyed Peas - I Gotta Feeling | 231 | 31 | 0.848 | 6/9/09 |
| 59 | +3 | Katy Perry - Teenage Dream | 184 | 1(16) | 2.581 | 7/23/10 |
| 60 | -3 | Mumford & Sons - Little Lion Man | 169 | 38 | 0.715 | 2/16/10 |
| 61 | -10 | Lil Wayne & Drake - Right Above It | 66 | 28 | 0.320 | 11/16/10 |
| 62 | -3 | Blake Shelton - Who Are You When I'm Not Looking | 78 | 50 | 0.319 | 8/6/10 |
| 63 | -20 | Kanye West & Jay-Z - H•A•M | 11 | 2 | 0.148 | 1/11/11 |
| 64 | = | Eminem - Love the Way You Lie (feat. Rihanna) | 217 | 1(33) | 3.217 | 6/21/10 |
| 65 | -7 | Dev & The Cataracs - Bass Down Low (feat. The Cataracs) | 32 | 41 | 0.140 | 12/7/10 |
| 66 | -10 | Lupe Fiasco - The Show Goes On | 33 | 18 | 0.213 | 10/25/10 |
| 67 | = | Linkin Park - Waiting for the End | 42 | 63 | 0.295 | 9/14/10 |
| 68 | -5 | Billy Currington - Let Me Down Easy | 37 | 63 | 0.211 | 9/21/10 |
| 69 | +14 | P!nk - Raise Your Glass | 90 | 39 | 0.333 | 10/6/10 |
| 70 | -1 | Jason Aldean - My Kinda Party | 81 | 33 | 0.319 | 11/2/10 |
| 71 | -1 | David Guetta & Rihanna - Who's That Chick? (feat. Rihan... | 23 | 33 | 0.149 | 11/22/10 |
| 72 | -6 | Enrique Iglesias - Tonight (I'm F**kin' You) [feat. Lud... | 62 | 13 | 0.338 | 11/22/10 |
| 73 | +4 | Train - Hey, Soul Sister | 222 | 14 | 1.159 | 8/7/09 |
| 74 | +6 | Enrique Iglesias - I Like It (feat. Pitbull) | 234 | 3 | 2.471 | 5/3/10 |
| 75 | -7 | James Blunt - Stay the Night | 5 | 61 | 0.018 | 1/18/11 |
| 76 | +10 | Ke$ha - Tik Tok | 145 | 28 | 0.707 | 1/4/09 |
| 77 | +4 | Yolanda Be Cool & Dcup - We No Speak Americano | 136 | 16 | 0.757 | 7/20/10 |
| 78 | +4 | Bruno Mars - Marry You | 64 | 37 | 0.234 | 10/5/10 |
| 79 | -6 | Eminem - No Love (feat. Lil Wayne) | 159 | 8 | 0.850 | 6/21/10 |
| 80 | -9 | Kanye West - All of the Lights | 14 | 57 | 0.105 | 11/22/10 |
| 81 | +3 | Eminem - Not Afraid | 222 | 5 | 1.798 | 6/21/10 |
| 82 | +13 | Taylor Swift - Mine | 90 | 16 | 0.419 | 10/25/10 |
| 83 | -4 | Lady Antebellum - Hello World | 16 | 46 | 0.161 | 1/26/10 |
| 84 | +4 | Jerrod Niemann - What Do You Want | 16 | 78 | 0.194 | 7/13/10 |
| 85 | +6 | Mike Posner - Cooler Than Me (Single Mix) | 210 | 4 | 2.195 | 4/19/10 |
| 86 | -12 | Dr. Dre - Kush (feat. Snoop Dogg & Akon) | 66 | 12 | 0.326 | 11/18/10 |
| 87 | -2 | Rihanna - S&M | 10 | 25 | 0.120 | 11/16/10 |
| 88 | +1 | Sara Evans - A Little Bit Stronger | 39 | 48 | 0.295 | 9/14/10 |
| 89 | +3 | Zac Brown Band - Colder Weather | 3 | 89 | 0.045 | 9/20/10 |
| 90 | +4 | Sara Bareilles - King of Anything | 138 | 16 | 0.560 | 9/7/10 |
| 91 | -19 | Jason Mraz - I'm Yours | 4 | 61 | 0.344 | 5/12/08 |
| 92 | -2 | Cali Swag District - Teach Me How to Dougie | 36 | 56 | 0.135 | 4/6/10 |
| 93 | = | Garrett Hedlund & Leighton Meester - Give In to Me | 16 | 34 | 0.068 | 12/21/10 |
| 94 | +7 | Mumford & Sons - The Cave | 1 | 94 | 0.193 | 2/16/10 |
| 95 | +9 | Ke$ha - Take It Off | 174 | 6 | 1.429 | 1/4/09 |
| 96 | +3 | The Ready Set - Love Like Woe | 181 | 14 | 0.998 | 6/14/10 |
| 97 | +5 | Chris Brown - Yeah 3X | 4 | 97 | 0.119 | 10/25/10 |
| 98 | +11 | Lady GaGa - Poker Face | 132 | 55 | 0.579 | 10/28/08 |
| 99 | -2 | Eric Church - Smoke a Little Smoke | 76 | 55 | 0.380 | 3/24/09 |
| 100 | -24 | Ke$ha - Sleazy (The Remix) [feat. Andre 3000] | 4 | 70 | 0.012 | 1/18/11 |
| 103 | -7 | Rick Ross - Aston Martin Music (feat. Drake & Chrisette... | 93 | 32 | 0.372 | 7/20/10 |
| 115 | +5 | Mann - Buzzin' | -- | 115 | 0.061 | 10/25/10 |
| 123 | -36 | Yellowcard - For You, and Your Denial | 4 | 35 | 0.021 | 1/18/11 |
| 127 | -29 | Nicki Minaj - Roman's Revenge (feat. Lil Wayne) | 3 | 83 | 0.010 | 1/19/11 |
| 146 | +12 | Ke$ha - Blow | -- | 146 | 0.037 | 11/19/10 |
| 151 | +40 | Katy Perry - Firework | 1 | 90 | 0.059 | 8/24/10 |
| 163 | +44 | Katy Perry - Hot N Cold | 21 | 53 | 0.274 | 6/17/08 |
| 179 | +24 | The Decemberists - Down By the Water | -- | 179 | 0.005 | 1/14/11 |
| 199 | +27 | Brandon Heath - Your Love | -- | 199 | 0.004 | 1/18/11 |
| 207 | +64 | Big Time Rush - Big Night | 12 | 55 | 0.089 | 10/11/10 |
| 217 | +64 | Sean Kingston - Fire Burning | -- | 156 | 0.246 | 4/24/09 |
| 251 | +63 | Justin Bieber - Somebody to Love | 79 | 20 | 0.501 | 3/23/10 |
| 259 | +127 | Hugo - 99 Problems | -- | 259 | 0.005 | 6/27/10 |
| 261 | +74 | Sean Kingston - Dumb Love | 17 | 30 | 0.192 | 9/7/10 |
| 267 | +195 | Bridgit Mendler - This Is My Paradise | -- | 257 | 0.008 | 1/11/11 |
| 272 | +438 | The Polar Bear Singers - Bear Down, Chicago Bears | -- | 272 | 0.002 | 2/6/07 |
| 278 | +424 | Big Time Rush - Til I Forget About You | 4 | 51 | 0.082 | 10/11/10 |
| 280 | +77 | Miley Cyrus - The Climb | -- | 117 | 0.214 | 3/24/09 |
| 321 | +125 | Queen - We Will Rock You | -- | 163 | 0.119 | 12/31/91 |
| 333 | +89 | Styx - Renegade | -- | 333 | 0.024 | 8/22/95 |
| 350 | +114 | Selena Gomez & The Scene - Naturally | 14 | 75 | 0.277 | 9/29/09 |
| 363 | +135 | Mr. C - Cha Cha Slide (Original Live Platinum Band Mix) | -- | 322 | 0.089 | 9/18/00 |
| 372 | +146 | Victorious Cast - Make It Shine (Victorious Theme) [fea... | -- | 129 | 0.153 | 4/13/10 |
| 380 | +470 | P!nk - Raise Your Glass | -- | 380 | 0.008 | 11/16/10 |
| 393 | +142 | Hannah Montana & Iyaz - Gonna Get This | 25 | 27 | 0.161 | 10/19/10 |
| 411 | +413 | Demi Lovato - What to Do | -- | 411 | 0.004 | 10/5/10 |
| 419 | +130 | Johnny Cash - Hurt | -- | 274 | 0.064 | 11/4/02 |
| 458 | +120 | The Beatles - Twist and Shout | 3 | 80 | 0.051 | 9/9/09 |
| 509 | +179 | Selena Gomez & The Scene - Round & Round | 3 | 63 | 0.078 | 9/21/10 |
| 620 | +160 | Queen - We Are the Champions | -- | 404 | 0.057 | 9/14/92 |
| 710 | +223 | Justin Bieber - One Less Lonely Girl | -- | 248 | 0.082 | 11/17/09 |
| 730 | +283 | Five for Fighting - Chances | -- | 188 | 0.081 | 6/15/10 |
| 760 | +203 | Crosby, Stills & Nash - Southern Cross | -- | 268 | 0.006 | 5/28/69 |
