| Pos | Pos+ | Artist and Title | Days | Peak | Pts | Released |
| 1 | = | Glee Cast - Forget You (Glee Cast Version) [feat. Gwyne... | 3 | 1(2) | 0.087 | 11/16/10 |
| 2 | = | Glee Cast - Singing In the Rain / Umbrella (feat. Gwyne... | 3 | 2 | 0.066 | 11/16/10 |
| 3 | = | Ke$ha - We R Who We R | 25 | 1(14) | 0.768 | 10/22/10 |
| 4 | = | Katy Perry - Firework | 35 | 2 | 0.494 | 8/24/10 |
| 5 | = | P!nk - Raise Your Glass | 43 | 4 | 0.700 | 10/6/10 |
| 6 | +5 | Cee Lo Green - F**k You | 63 | 6 | 0.535 | 9/14/10 |
| 7 | -1 | The Black Eyed Peas - The Time (Dirty Bit) | 11 | 2 | 0.228 | 11/9/10 |
| 8 | = | Far East Movement, The Cataracs & Dev - Like a G6 | 108 | 1(16) | 2.098 | 10/9/10 |
| 9 | = | Rihanna - Only Girl (In the World) | 67 | 1(8) | 1.526 | 9/13/10 |
| 10 | = | Nelly - Just a Dream | 95 | 2 | 1.926 | 8/17/10 |
| 11 | +2 | Trey Songz - Bottoms Up (feat. Nicki Minaj) | 66 | 5 | 0.844 | 9/14/10 |
| 12 | +2 | Bruno Mars - Grenade | 45 | 12 | 0.239 | 10/5/10 |
| 13 | -1 | Glee Cast - Teenage Dream (Glee Cast Version) | 11 | 1(4) | 0.247 | 11/9/10 |
| 14 | +1 | Bruno Mars - Just the Way You Are | 122 | 1(12) | 2.429 | 7/20/10 |
| 15 | +4 | Willow - Whip My Hair | 25 | 2 | 0.394 | 10/26/10 |
| 16 | +294 | Dr. Dre - Kush (feat. Snoop Dogg & Akon) | 1 | 16 | 0.010 | 11/18/10 |
| 17 | = | Cee Lo Green - Forget You | 25 | 17 | 0.163 | 9/14/10 |
| 18 | +3 | Wiz Khalifa - Black and Yellow | 57 | 17 | 0.324 | 9/14/10 |
| 19 | -3 | Sugarland - Stuck Like Glue | 22 | 9 | 0.179 | 10/19/10 |
| 20 | = | OneRepublic - Secrets | 148 | 16 | 0.955 | 11/17/09 |
| 21 | +1 | Taio Cruz - Dynamite | 169 | 1(6) | 3.134 | 6/1/10 |
| 22 | +1 | The Band Perry - If I Die Young | 37 | 14 | 0.260 | 10/12/10 |
| 23 | +5 | Mike Posner - Please Don't Go | 49 | 12 | 0.403 | 8/10/10 |
| 24 | +2 | Usher - DJ Got Us Fallin' In Love (feat. Pitbull) | 129 | 2 | 2.048 | 6/25/10 |
| 25 | -7 | The Beatles - Here Comes the Sun | 3 | 18 | 0.023 | 9/26/69 |
| 26 | +5 | Waka Flocka Flame - No Hands (feat. Roscoe Dash & Wale) | 73 | 14 | 0.480 | 9/6/10 |
| 27 | +2 | Flo Rida - Club Can't Handle Me (feat. David Guetta) [F... | 139 | 5 | 1.611 | 6/28/10 |
| 28 | +2 | Neon Trees - Animal | 169 | 12 | 1.027 | 3/16/10 |
| 29 | -2 | Rihanna - S&M | 3 | 25 | 0.021 | 11/16/10 |
| 30 | +2 | Katy Perry - Teenage Dream | 119 | 1(16) | 2.270 | 7/23/10 |
| 31 | +5 | Nelly & Keri Hilson - Liv Tonight | 3 | 31 | 0.016 | 11/16/10 |
| 32 | +6 | Rihanna & Drake - What's My Name? | 3 | 32 | 0.016 | 11/16/10 |
| 33 | +2 | The Ready Set - Love Like Woe | 116 | 14 | 0.680 | 6/14/10 |
| 34 | -10 | The Beatles - Let It Be | 3 | 24 | 0.019 | 5/8/70 |
| 35 | -10 | The Beatles - In My Life | 3 | 25 | 0.019 | 12/3/65 |
| 36 | +3 | Pitbull - Hey Baby (Drop It to the Floor) [feat. T-Pain... | 52 | 16 | 0.323 | 9/17/10 |
| 37 | +3 | Enrique Iglesias - I Like It (feat. Pitbull) | 169 | 3 | 2.217 | 5/3/10 |
| 38 | +3 | Yolanda Be Cool & Dcup - We No Speak Americano | 71 | 16 | 0.490 | 7/20/10 |
| 39 | +5 | Nicki Minaj - Right Thru Me | 51 | 35 | 0.200 | 9/24/10 |
| 40 | +5 | Tim McGraw - Felt Good On My Lips | 17 | 11 | 0.118 | 11/2/10 |
| 41 | -7 | The Beatles - Come Together | 3 | 34 | 0.016 | 9/26/69 |
| 42 | +1 | Zac Brown Band - As She's Walking Away (feat. Alan Jack... | 57 | 29 | 0.236 | 9/20/10 |
| 43 | +3 | Sean Kingston - Letting Go (Dutty Love) [feat. Nicki Mi... | 108 | 14 | 0.664 | 8/3/10 |
| 44 | -11 | The Beatles - Blackbird | 3 | 33 | 0.016 | 11/22/68 |
| 45 | +9 | Kenny Chesney - Somewhere With You | 17 | 45 | 0.086 | 9/28/10 |
| 46 | +4 | Eminem - Love the Way You Lie (feat. Rihanna) | 152 | 1(33) | 2.943 | 6/21/10 |
| 47 | +6 | Christina Perri - Jar of Hearts | 35 | 40 | 0.239 | 7/27/10 |
| 48 | -6 | Ke$ha - Blow | 3 | 33 | 0.016 | 11/12/10 |
| 49 | +8 | Edward Maya & Vika Jigulina - Stereo Love | 40 | 46 | 0.253 | 2/2/10 |
| 50 | +1 | Lupe Fiasco - The Show Goes On | 10 | 18 | 0.060 | 11/9/10 |
| 51 | +7 | Eminem - No Love (feat. Lil Wayne) | 94 | 8 | 0.546 | 6/21/10 |
| 52 | +4 | Taylor Swift - Mine | 25 | 16 | 0.158 | 10/25/10 |
| 53 | -1 | Jason Aldean - Don't You Wanna Stay (with Kelly Clarkso... | 17 | 18 | 0.086 | 11/2/10 |
| 54 | +5 | Kanye West - Runaway (feat. Pusha T) | 47 | 2 | 0.360 | 10/4/10 |
| 55 | +5 | Jeremih & 50 Cent - Down On Me (feat. 50 Cent) | 10 | 33 | 0.088 | 9/28/10 |
| 56 | -9 | The Beatles - Hey Jude | 3 | 47 | 0.012 | 4/19/73 |
| 57 | +11 | Chris Brown - Yeah 3X | 25 | 12 | 0.142 | 10/26/10 |
| 58 | +11 | Jesse McCartney - Shake | 46 | 47 | 0.185 | 9/21/10 |
| 59 | +7 | Ke$ha - Take It Off | 120 | 6 | 1.228 | 1/4/09 |
| 60 | -23 | Glee Cast - Nowadays / Hot Honey Rag (Glee Cast Version... | 3 | 37 | 0.014 | 11/16/10 |
| 61 | +9 | Jason Aldean - My Kinda Party | 16 | 33 | 0.072 | 11/2/10 |
| 62 | -7 | Glee Cast - Start Me Up / Livin' On a Prayer (Glee Cast... | 11 | 2 | 0.110 | 11/9/10 |
| 63 | +9 | Mumford & Sons - Little Lion Man | 104 | 38 | 0.482 | 2/16/10 |
| 64 | +1 | Flo Rida - Turn Around (5,4,3,2,1) | 3 | 64 | 0.011 | 11/16/10 |
| 65 | +11 | Florence + The Machine - Dog Days Are Over | 87 | 3 | 0.477 | 7/5/09 |
| 66 | +76 | Lil Wayne & Drake - Right Above It | 1 | 66 | 0.005 | 11/16/10 |
| 67 | -5 | Rihanna & Nicki Minaj - Raining Men | 3 | 62 | 0.011 | 11/16/10 |
| 68 | +13 | Sara Bareilles - King of Anything | 73 | 16 | 0.344 | 9/7/10 |
| 69 | -20 | Carrie Underwood - There's a Place for Us | 3 | 32 | 0.015 | 11/16/10 |
| 70 | +9 | Taylor Swift - Back to December | 22 | 31 | 0.089 | 10/25/10 |
| 71 | +19 | P!nk - Raise Your Glass | 25 | 58 | 0.102 | 10/6/10 |
| 72 | +14 | Rick Ross - Aston Martin Music (feat. Drake & Chrisette... | 37 | 32 | 0.186 | 7/20/10 |
| 73 | -10 | The Beatles - Let It Be | 3 | 63 | 0.010 | 9/9/09 |
| 74 | +19 | Plain White T's - Rhythm of Love | 91 | 46 | 0.321 | 8/10/10 |
| 75 | -4 | P!nk - F**kin' Perfect | 3 | 66 | 0.011 | 11/16/10 |
| 76 | -15 | The Beatles - With a Little Help From My Friends | 3 | 55 | 0.011 | 6/1/67 |
| 77 | +11 | will.i.am & Nicki Minaj - Check It Out | 73 | 25 | 0.384 | 9/3/10 |
| 78 | +14 | Usher - Hot Tottie (feat. Jay-Z) | 87 | 17 | 0.470 | 8/24/10 |
| 79 | -2 | Kid Cudi - Marijuana | 10 | 17 | 0.061 | 11/9/10 |
| 80 | -7 | Glee Cast - O Holy Night (Glee Cast Version) | 2 | 73 | 0.009 | 11/16/10 |
| 81 | +10 | Lady Antebellum - Hello World | 7 | 46 | 0.040 | 1/26/10 |
| 82 | +18 | Kanye West, Jay-Z, Rick Ross, Nicki Minaj & Bon Iver - ... | 26 | 9 | 0.189 | 10/23/10 |
| 83 | -35 | Glee Cast - Make 'Em Laugh (Glee Cast Version) | 3 | 48 | 0.012 | 11/16/10 |
| 84 | +15 | Eric Church - Smoke a Little Smoke | 52 | 55 | 0.231 | 3/24/09 |
| 85 | -18 | The Beatles - While My Guitar Gently Weeps | 3 | 67 | 0.010 | 11/22/68 |
| 86 | +11 | Blake Shelton - Who Are You When I'm Not Looking | 14 | 67 | 0.098 | 8/6/10 |
| 87 | -7 | The Beatles - Yesterday | 3 | 80 | 0.009 | 9/9/09 |
| 88 | -13 | The Beatles - I Saw Her Standing There | 3 | 75 | 0.009 | 3/22/63 |
| 89 | +6 | Natasha Bedingfield - Strip Me | 36 | 53 | 0.152 | 9/21/10 |
| 90 | NEW | Michael Jackson - Hold My Hand (Duet with Akon) | 1 | 90 | 0.003 | 11/18/10 |
| 91 | -17 | The Beatles - A Day In the Life | 3 | 74 | 0.009 | 6/1/67 |
| 92 | +11 | Akon - Angel | 24 | 20 | 0.160 | 9/17/10 |
| 93 | -10 | The Beatles - Something | 3 | 83 | 0.008 | 9/26/69 |
| 94 | +16 | B.o.B - Magic (feat. Rivers Cuomo) | 156 | 6 | 1.355 | 4/27/10 |
| 95 | -17 | The Beatles - Eleanor Rigby | 3 | 75 | 0.009 | 8/5/66 |
| 96 | -14 | The Beatles - Ob-La-Di, Ob-La-Da | 3 | 82 | 0.008 | 11/22/68 |
| 97 | +20 | Rihanna - Only Girl (In the World) | 1 | 97 | 0.007 | 11/16/10 |
| 98 | +27 | Cali Swag District - Teach Me How to Dougie | 148 | 28 | 0.666 | 4/6/10 |
| 99 | -14 | The Beatles - Twist and Shout | 3 | 80 | 0.008 | 9/9/09 |
| 100 | +9 | Katy Perry - California Gurls (feat. Snoop Dogg) | 167 | 1(29) | 2.620 | 5/7/10 |
| 101 | -14 | The Beatles - Lucy In the Sky With Diamonds | 2 | 87 | 0.008 | 6/1/67 |
| 103 | +28 | Lady Antebellum - Need You Now | 66 | 38 | 0.276 | 1/26/10 |
| 104 | -15 | The Beatles - Help! | 2 | 89 | 0.008 | 8/6/65 |
| 105 | -11 | The Beatles - Can't Buy Me Love | 1 | 94 | 0.007 | 7/10/64 |
| 106 | -10 | Glee Cast - One Love (People Get Ready) [Glee Cast Vers... | 9 | 8 | 0.067 | 11/9/10 |
| 107 | -23 | The Beatles - Yesterday | 2 | 84 | 0.008 | 8/6/65 |
| 111 | -13 | The Beatles - A Hard Day's Night | 1 | 98 | 0.007 | 7/10/64 |
| 118 | +33 | Nicki Minaj - Roman's Revenge (feat. Eminem) | 14 | 17 | 0.077 | 10/31/10 |
| 119 | +44 | Train - Marry Me | -- | 114 | 0.065 | 10/26/09 |
| 121 | +32 | Rodney Atkins - Farmer's Daughter | 113 | 59 | 0.383 | 6/29/10 |
| 126 | +72 | Keri Hilson - Pretty Girl Rock | 3 | 85 | 0.036 | 10/12/10 |
| 145 | +40 | Thompson Square - Are You Gonna Kiss Me or Not | -- | 132 | 0.060 | 8/3/10 |
| 146 | +50 | B.o.B - Don't Let Me Fall | -- | 146 | 0.026 | 4/27/10 |
| 147 | +42 | Shakira - Waka Waka (This Time for Africa) [The Officia... | 146 | 19 | 0.663 | 5/11/10 |
| 152 | +50 | Mariah Carey - All I Want for Christmas Is You (Origina... | -- | 152 | 0.015 | 12/31/93 |
| 159 | +42 | Usher - OMG (feat. will.i.am) | 148 | 2 | 1.604 | 3/30/10 |
| 177 | +56 | Keith Urban - Put You In a Song | -- | 177 | 0.003 | 11/16/10 |
| 180 | +41 | Rascal Flatts - Why Wait | -- | 180 | 0.003 | 11/16/10 |
| 189 | +52 | The Black Keys - Tighten Up | 4 | 89 | 0.224 | 5/18/10 |
| 190 | +53 | Troop 41 - Do the John Wall | -- | 184 | 0.051 | 2/23/09 |
| 197 | +69 | Lee DeWyze - Beautiful Like You | -- | 197 | 0.003 | 11/16/10 |
| 199 | +53 | Taylor Swift - Sparks Fly | 19 | 1(1) | 0.241 | 10/25/10 |
| 200 | +60 | Reba McEntire - Turn On the Radio | -- | 176 | 0.011 | 11/9/10 |
| 202 | +95 | Chiddy Bang - Opposite of Adults | -- | 202 | 0.027 | 10/12/10 |
| 205 | +64 | Eminem - Lose Yourself | -- | 108 | 0.306 | 10/29/02 |
| 206 | +55 | Miguel - All I Want Is You (feat. J. Cole) | -- | 128 | 0.177 | 5/21/10 |
| 208 | +56 | will.i.am & Nicki Minaj - Check It Out (Main Radio Mix) | 11 | 84 | 0.113 | 9/8/10 |
| 210 | +84 | Mumford & Sons - The Cave | -- | 163 | 0.086 | 2/16/10 |
| 212 | +196 | Lil Wayne & Drake - Gonorrhea | -- | 212 | 0.002 | 11/16/10 |
| 213 | +72 | Sick Puppies - Maybe | -- | 139 | 0.026 | 10/22/10 |
| 217 | +215 | Lee DeWyze - Sweet Serendipity | -- | 217 | 0.002 | 11/16/10 |
| 220 | +59 | Kid Cudi - Pursuit of Happiness (Nightmare) [feat. MGMT... | 16 | 61 | 0.332 | 9/15/09 |
| 232 | +73 | Good Charlotte - Like It's Her Birthday | 3 | 64 | 0.107 | 8/20/10 |
| 235 | +83 | T.I. - Get Back Up (feat. Chris Brown) | 7 | 33 | 0.046 | 10/29/10 |
| 237 | +63 | Drake, Kanye West, Lil Wayne & Eminem - Forever | 1 | 100 | 0.277 | 9/29/09 |
| 239 | +74 | Diddy - Dirty Money - Loving You No More (feat. Drake) | 5 | 42 | 0.070 | 9/21/10 |
| 241 | +74 | Lil Wayne & Eminem - Drop the World | 20 | 80 | 0.288 | 2/2/10 |
| 242 | +62 | Taylor Swift - Better Than Revenge | 15 | 10 | 0.106 | 10/25/10 |
| 244 | +67 | La Roux - Bulletproof | 129 | 9 | 0.940 | 9/22/09 |
| 246 | +85 | Soulja Boy Tell'em - Pretty Boy Swag | 93 | 38 | 0.489 | 6/8/10 |
| 249 | +90 | Cali Swag District - Teach Me How to Dougie | -- | 113 | 0.169 | 4/6/10 |
| 250 | +84 | Wiz Khalifa - Black and Yellow | -- | 239 | 0.021 | 9/14/10 |
| 256 | +82 | Chris Tomlin - Our God | -- | 256 | 0.002 | 11/12/10 |
| 275 | +75 | Wiz Khalifa - Say Yeah | -- | 213 | 0.065 | 1/22/08 |
| 278 | +146 | En Vogue - Free Your Mind | -- | 196 | 0.006 | 8/20/01 |
| 282 | +111 | Sunny Sweeney - From a Table Away | -- | 234 | 0.035 | 6/29/10 |
| 285 | +88 | Israel Kamakawiwo'ole - Somewhere Over the Rainbow | 5 | 63 | 0.227 | 9/25/01 |
| 287 | +111 | Nelly, Akon & T-Pain - Move That Body | -- | 287 | 0.002 | 11/16/10 |
| 291 | +75 | Wiz Khalifa - This Plane | -- | 216 | 0.074 | 11/24/09 |
| 293 | +81 | LMFAO & Lil Jon - Shots | 1 | 94 | 0.284 | 7/7/09 |
| 299 | +88 | MGMT - Kids | -- | 162 | 0.189 | 2/12/08 |
| 301 | +275 | Lil Wayne - Bill Gates | -- | 301 | 0.001 | 11/16/10 |
| 302 | +87 | Michael Franti & Spearhead - Say Hey (I Love You) [feat... | 20 | 57 | 0.316 | 8/18/09 |
| 306 | +90 | Taylor Swift - Mean | 8 | 62 | 0.054 | 10/25/10 |
| 307 | +116 | Waka Flocka Flame - No Hands (feat. Roscoe Dash and Wal... | -- | 240 | 0.046 | 9/7/10 |
| 310 | +84 | Sanctus Real - Lead Me | -- | 159 | 0.143 | 7/2/10 |
| 312 | +95 | Michael Bublé - Hollywood | 5 | 91 | 0.032 | 10/25/10 |
| 313 | +102 | Trans-Siberian Orchestra - Christmas / Sarajevo 12/24 (... | -- | 313 | 0.008 | 10/14/96 |
| 315 | +82 | Miley Cyrus - Party In the U.S.A. | 49 | 56 | 0.340 | 8/11/09 |
| 318 | +102 | DJ Khaled - All I Do Is Win (feat. T-Pain, Ludacris, Sn... | -- | 149 | 0.201 | 2/9/10 |
| 319 | +93 | Flo Rida - Right Round | -- | 128 | 0.223 | 3/30/09 |
| 328 | +139 | Lee DeWyze - Live It Up | -- | 328 | 0.002 | 11/16/10 |
| 329 | +327 | Diddy - Dirty Money - Hello Good Morning (feat. T.I.) | 69 | 30 | 0.375 | 3/30/10 |
| 331 | +86 | Lifehouse - All In | -- | 249 | 0.089 | 3/2/10 |
| 335 | +214 | Lloyd Banks - Start It Up (feat. Kanye West, Swizz Beat... | -- | 335 | 0.001 | 11/2/10 |
| 337 | +123 | Phoenix - Lisztomania | -- | 146 | 0.175 | 5/12/09 |
| 340 | +93 | a-ha - Take On Me | -- | 140 | 0.019 | 7/19/05 |
| 342 | +115 | Deadmau5 - Ghosts N Stuff | -- | 103 | 0.125 | 11/25/08 |
| 345 | +98 | Kanye West - Power | 93 | 9 | 0.480 | 7/1/10 |
| 346 | +90 | Linkin Park - The Catalyst | 36 | 15 | 0.201 | 9/14/10 |
| 349 | +102 | Faith Hill - Where Are You Christmas | -- | 336 | 0.008 | 11/7/00 |
| 352 | +97 | Eminem - Love the Way You Lie (feat. Rihanna) | 109 | 26 | 0.546 | 6/21/10 |
| 360 | +117 | Cupid - Cupid Shuffle | -- | 162 | 0.174 | 9/11/07 |
| 362 | +238 | Lil Wayne - I Am Not a Human Being | -- | 362 | 0.001 | 11/16/10 |
| 374 | +98 | Broken Bells - The High Road | -- | 199 | 0.147 | 3/5/10 |
| 375 | +111 | Twista - Make a Movie (feat. Chris Brown) | -- | 214 | 0.030 | 8/24/10 |
| 377 | +261 | Sean Hayes - Powerful Stuff | -- | 302 | 0.007 | 3/16/10 |
| 380 | +100 | Iyaz - Replay | -- | 114 | 0.220 | 8/11/09 |
| 390 | +100 | Afrojack - Take Over Control (Radio Edit) [feat. Eva Si... | -- | 246 | 0.037 | 9/17/10 |
| 391 | +154 | Chris Brown - Yeah 3X | -- | 263 | 0.015 | 10/26/10 |
| 395 | +103 | Jackie Evancho - O Holy Night | -- | 395 | 0.002 | 11/16/10 |
| 401 | +117 | Rascal Flatts - Bless the Broken Road | -- | 105 | 0.076 | 9/28/04 |
| 402 | +108 | Cage the Elephant - Ain't No Rest for the Wicked | -- | 178 | 0.160 | 3/24/09 |
| 404 | +131 | Justin Moore - How I Got to Be This Way | -- | 200 | 0.072 | 8/11/09 |
| 405 | +404 | Lil Wayne & Drake - Right Above It | -- | 405 | 0.001 | 11/16/10 |
| 407 | +122 | Kanye West - Stronger | -- | 195 | 0.123 | 9/11/07 |
| 409 | +401 | Jamie Foxx - Fall for Your Type (feat. Drake) | -- | 409 | 0.001 | 11/16/10 |
| 411 | +120 | T-Pain - Rap Song (feat. Rick Ross) | 4 | 51 | 0.043 | 10/15/10 |
| 415 | +123 | Like A G6 - Like A G6 (feat. Daun & Alberta) | -- | 261 | 0.008 | 10/27/10 |
| 423 | +141 | Usher - There Goes My Baby | 57 | 72 | 0.322 | 3/30/10 |
