Just read the article, most of it is covered in the OP. A few more things:
There are 60 different animations just of Drake picking up objects.
Talk a lot about how weight distribution plays a big role in the animations
You can attack enemies from all sides with unique animations to them, you wont magically warp in front of them if you punch.
Lots of talk from Druckman on the cost of adventuring on Drake's life, it will be a major focus of the story. Compares his addiction to treasure hunting to a drug addict.
All the new items they added were chosen cause it can help keep the pacing and gives you a better sense of exploration and adventure.
Cutscenes are now all real time
Tools will be used to enhance traversal and puzzle solving
They said the large puzzle rooms from Uncharted 3 will still be there, they say U3 had the best puzzles of the series and they want to build on that.
TLOU moments where the characters react to what they see or read will happen in this game.
Lots of talk about brotherly banter and building a bond between the NPC and the player, "there are some nice cooperative moments between Nate and his brother."
On the gigantic setpieces, this is exactly what they say "So now our concept of a set piece is 'what's something impactful we can do to switch expectations and how can we have it emotionally charged?' We want to constantly surprise the player, so it can be really intimate, or really big and bombastic."
