Nope. His mainstream career has definitely been harmed, but it's been this way for a long time and given his focus on urban music lately, I think he's accepted it.
His career in the urban market is far from over. He's already got 3 smash hits on the urban and rhythmic format and he didn't even promote 2 of them. He's established. I bet his album will outsell certain pop girls in the first week too