iTunes. It's the only software that allows me to organize my stuff the way I like and has a nice interface.
They need to bring coverflow back, though. Or at least adjustable size for the covers.
Spotify and iTunes both. I use Spotify to listen to music (along with the Local Files playlist to play downloaded songs) but I use iTunes to change album data and sync music to my iPhone. I don't use Local Files on my iPhone because it's too much work to sync so I just use the Music app, but I still use Spotify for streaming.