Superman has Lex Luther, Batman has the Joker, Captain America has the Red Skull, but Spiderman's can be debated between three choices instead of just one like so many heroes. Is it...
Green Goblin definitely (killing Gwen Stacy, drama with Harry,etc. )
Im pretty sure Spider-Man teams up with Venom from time to time (esp. when he turns into Agent Venom )
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