Alexis Arquette died Sunday morning surrounded by family and friends ... the family confirms to TMZ.
Alexis' brother, Richmond Arquette says Alexis died at 12:32 AM while listening to David Bowie's, "Starman."
Besides being the sibling of David and Patricia Arquette -- Alexis was known for her roles in "Pulp Fiction" and "The Wedding Singer," as well as being a champion for trans rights.