About best actor and actress in a Drama Series:
I think Cranston has it in the bag again! No doubt about that. I think Jon Hamm, Hugh Laurie and Steve Buscemi will be nominated yet again, and I think Damien Lewis (Homeland) and Kelsey Grammer (Boss) will be nominated, too.
Best actress is more interesting this year because Claire Danes is going to be serious competition and probably block Julianna Margulies. It's between those two. Glenn Close and Elisabeth Moss have the nod in the bag, and I really, really hope Jessica Paré will be nominated too. I thought she was terrific on Mad Men this season and she totally deserves it. Debra Messing is an Emmy favorite so she could be, but Mariska Hargitay and Kathy Bates are strong contenders, too.
Edit: I totally forgot about Emmy Rossum, she's oustanding on Shameless, she definitely deserves a nomination.